臨床醫學研究所

歡迎光臨成功大學臨床醫學研究所
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陳芃潔 助理教授

陳芃潔 (Chen, Peng-Chieh)

助理教授

電話:(06)2353535 ext.4144

 E-mail: pengchic@mail.ncku.edu.tw

實驗室簡介:Laboratory of Human Molecular Genetics

 

 

 

學歷:

1997-2001 學士 國立清華大學
2001-2006 博士 美國加州大學爾灣分校

 

 

經歷:

2007-2012 研究員 哈佛醫學院
2007-2012 博士後研究員 伯明罕婦女醫院
2012-present 助理教授

國立成功大學臨床醫學研究所

 

 

 

 

 

開授課程:

      Advanced Biotechnology 分子技術特論

       PBL-Pathophysiology 病態生理學

      Seminar 專題討論 (碩)

近五年代表作:

  1. Tsai MC, Yu HW, Liu TL, Chou YY, Chiou YY, Chen PC*. Rare Compound Heterozygous Frameshift Mutations in ALMS1 Gene Identified Through Exome Sequencing in a Taiwanese Patient With Alström Syndrome. Frontiers in Genetics. 2018; Apr 18;9:110.

  2. Liao CY, Yu HW, Cheng CN, Chen JS, Lin CW, Chen PC*, Shieh CC*. A Novel Pathogenic Mutation on Interleukin-7 Receptor Leading to Severe Combined Immunodeficiency Identified with Newborn Screening and Whole Exome Sequencing. JMII. 2018; 1182(18)30049-5.

  3. Chen PCYin J, Yu HW, Yuan T, Fernandez M, Yung CK, Trinh Q, Reid JG, Tworog-Dube E, Morgan MB, Muzny D, Stein L, McPherson JD, Roberts AE, Gibbs RA, Neel BG, Kucherlapati R. Next generation sequencing identifies novel, rare variants associated with Noonan syndrome. PNAS. 2014; 111(31): 11473-8. 

  4. The Cancer Genome Atlas Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature2014; 511: 543-550.

  5. The Cancer Genome Atlas Network. The somatic genomic landscape of glioblastoma. Cell. 2013; 155(2): 462-77.

  6. The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer.Nature. 2012; 487: 330–337.

  7. The Cancer Genome Atlas Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012; 489: 519-25.

  8. Roper J, Richardson MP, Wang WV, Richard LG, Chen W, Coffee EM, Sinnamon MJ, Lee L, Chen PC, Bronson RT, Martin ES, Hung KE. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS One. 2011; 6(9): e25132.

  9. Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG and Kucherlapati R. Activation of multiple signaling pathways causes cardiac defects in mice with Noonan syndrome-associated Sos1 mutation. Journal of Clinical Investigation. 2010; 120(12): 4353.

  10. Chen PC, Kuraguchi M, Velasquez J, Wang Y, Yang K, Edwards R, Gillen D, Edelmann W, Kucherlapati R, Lipkin SM. Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal yumorigenesis and progression. PLoS Genetics. 2008; 4(6): e1000092.

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最後更新日期
2018-07-18