跳到主要內容區塊

呂佩融 教授

呂佩融 (Lu, Pei-Jung ) 

教授

電話:(06)2353535 ext.4415

傳真:(06)2758781 

 E-mail: pjlu2190@mail.ncku.edu.tw

實驗室簡介:Laboratory of Signal Transduction and Molecular Cancer Research

 

 

 

學歷

1993.01-1997.12 美國肯塔基大學藥學博士

經歷:

2013.08~         國立成功大學臨床醫學所特聘教授
2009.08~2013.07  國立成功大學臨床醫學所教授
2007.08-2009.07  國立成功大學臨床醫學所副教授
2003.08-2007.07 高雄榮民總醫院副研究員
2002.02-2003.07 國立中山大學生物醫學所副教授
2001.02-2002.02 國立中山大學生物醫學所助理教授
1998.01-2001.02 美國哈佛大學醫學院醫學系博士後研究

開授課程:

1. Signal Transduction and Dug Development,
2. Translational Medicine,
3. Cell Death & Disease

近五年代表作(selected publications from 62 papers)

1. P.I. Hsu, C.H. Chen, Hsiao, H.C. Chen, and P.J. Lu* (2010) Diagnosis of Gastric Malignancy Using Gastric Juice a1-antitrypsin, Cancer Epidemiology, Biomarkers & Prevention, 19: 405-411. (SCI=4.190, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, 12/142=8.4%)

2. Y.W. Wei, C.H. Lee, Y.T. Huang, Y.C. Lee, K.H. Lee and P.J. Lu.*(2010)CDK5 phosphorylates eNOS at Ser113 and regulates NO production. Journal of Cellular Biochemistry. 110: 112-117.(SCI. IF=3.122, BIOCHEMISTRY & MOLECULAR BIOLOGY, 125/286=43.7)

3. K.H. Hsu, H.W. Tsai, P.W. Lin, Y.S. Hsu, Y.S. Shan, and P.J. Lu*(2010)Clinical Implication and Mitotic Effect of CD44 Cleavage in Relation to Osteopontin/CD44 Interaction and Dysregulated Cell Cycle Protein in Gastrointestinal Stromal Tumor. Ann. Surg. Oncol. 8: 2199-2212. (SCI. IF= 4.182, SURGERY, 8/188=4.2)

4. K.H. Hsu, H.W. Tsai, P.W. Lin, Y.S. Hsu, Y.S. Shan, P.J. Lu *.(2010) Osteopontin Expression is an Independent Adverse Prognostic Factor in Resectable Gastrointestinal Stromal Tumor and its Interaction with CD44 Promotes Tumor Proliferation. Ann Surg Oncol. 17: 3043-52. (SCI. IF= 4.182, SURGERY, 8/188=4.2)

5. P.J. Lu, P.I. Hsu, C.H. Chen, M. Hsiao, W.C. Chang, H.H. Tseng, K.H. Lin, S.K. Chuah, H.C. Chen.(2010)Gastric juice acidity in upper gastrointestinal diseases. World J Gastroenterol. 16: 5496-501. (SCI. IF= 2.24)

6. Y.W. Chen, Y.L. Chen, C.H. Tseng, C.C. Liang, C.N. Yang, Y.C. Yao, P.J. Lu*, CC Tzemg*.(2011)Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small cell lung cancers. Journal of Medicinal Chemistry, *Co-Correspondence. 54: 4446-4461. (SCI. IF= 5.207 , CHEMISTRY, MEDICINAL , 3/54=5.5%)

7. H.Y. Wang, L.I. Juo, Y.T. Lin, N.S. Chang, Y.H. Tzeng, Y.C. Chuang, C.N. Yang, P.J. Lu* (2012) WW domain-containing oxidoreductase promotes neuronal differentiation via negatively regulation of glycogen synthase kinase 3 beta. Cell Death and Differentiation. 19: 1049-59. (SCI. IF= 9.505, BIOCHEMISTRY & MOLECULAR BIOLOGY, 24/286=8.3%)

8.F.C. Lin, C.H. Lai, Y.S. Shan, P.I. Hsu, C.H. Lee, C.H. Wang, J.Q. Cheng, M. Hsiao*, P.J. Lu*.(2012)RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Oncogene. 31, 4302–4316. (SCI. IF= 6.373, ONCOLOGY, 19/196=9.6%)

9. J.T. Lin, T.S. Tzai, C.Y. Liao, J.S. Wang, T.T. Wu, C.C. Yu, P.J. Lu*.(2013)WWOX protein expression varies among RCC histotypes and down-regulation of WWOX protein correlates with less-favorable prognosis in clear RCC. Ann. Surg. Oncol. 20:193-9. (SCI. IF= 4.182, SURGERY, 8/188=4.2)

10.Y.P. Liu, C.J. Yang, M.S. Huang, C.T. Yeh, Alexander T.H. Wu, Y.C. Lee, T.C. Lai, C.H. Lee, Y.W. Hsiao, Jean Lu, C.N. Shen, P.J. Lu*, and Michael Hsiao*. (2013) Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Research. 73: 406-16. (SCI. IF= 9.284, ONCOLOGY, 11/196=5.6)

11. Y.C. Lee, P.-C. Liao, Y.C. Liou, Michael Hsiao, C.Y. Huang and P.J. Lu*. (2013)Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry. Cell Cycle. 12: 953-60. (SCI. IF= 5.243, CELL BIOLOGY, 44/184=23.9)

12. Y.H. Lo, Y.T. Lin, Y.P. Liu, T.H. Duh, P.J. Lu*, M.J. Wu*.(2013) Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3(Z)-hexen-1,5-diynes as a new class of potent antitumor agents. Eur J Med Chem. 62: 526-533. *Co-Correspondence. (SCI. IF= 3.499, CHEMISTRY, MEDICINAL, 13/59=22)

13. Y.C. Lee, J. Que, Y.C. Chen, J.T. Lin, Y.C. Liou, P.C. Liao, Y.P. Liu, K.H. Lee, L.C. Lin, M. Hsiao, L.Y. Hung, C.Y. Huang, P.J. Lu*.(2013)Pin1 acts as a negative regulator of the G2/M transition through an interplay with the Aurora A/hBora complex. J Cell Sci. 126, 4862–4872. (SCI. IF= 5.877, CELL BIOLOGY, 38/184=20.65)

14. Y.P. Liu, W.C. Liao, L.P. Ger, J.C. Chen, T.I. Hsu, Y.C. Lee, H.T. Chang, Y.C. Chen, Y.H. Jan, K.H. Lee, Y.H. Zeng, M. Hsiao, P.J. Lu.*(2013)Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer. Cancer Res. 73(20):6194-205. (SCI. IF= 9.284, ONCOLOGY, 11/196=5.6)

15. H.C. Cheng, Y.P. Liu, Y.S. Shan, C.Y. Huang, F.C. Lin, L.C. Lin, L. Lee, C.H. Tsai, M. Hsiao, P.J. Lu.*(2013)Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer. Carcinogenesis. 34 (11):2452-2459. (SCI. IF= 5.635, ONCOLOGY, 28/196=14.2)

16. H.Y. Wang, C.M. Fu, Y.C. Lee, P.J. Lu*(2013)Hyperthermia stress activates heat shock protein expression via propyl isomerase 1 regulation with heat shock factor 1. Mol. Cell. Biol. 33(24):4889-4899.(SCI. IF= 5.372)

17. F.C. Lin, Y.C. Lee, Y.G. Goan, C.H. Tsai, Y.C. Yao, H.C. Cheng, W.W. Lai, Y.C. Wang , B.S. Sheu, P.J. Lu*.(2014)Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients. J Biomed Sci. 21(1):75. (SCI. IF=2.74)

18. J.T. Lin, H.Y. Li, P.J. Lu*(2014)WWOX suppresses prostate cancer cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase. Cell Cycle. In Press. (SCI. IF=5.006)

19. T.I. Hsu, C.H. Hsu, K.H. Lee, J.T. Lin, C.S. Chen, K.C. Chang, C.Y. Joy Su, M. Hsiao, P.J. Lu*.(2014)MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis. 3:e99.

20. K.H. Lee, F.C. Lin, T.I Hsu, J.T. Lin, J.H. Guo, C.H. Tsai, Y.C. Lee, C.L. Chen, M. Hsiao, P.J. Lu*.(2014)MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1. Biochim Biophys Acta- Molecular Cell Research. 1843(9):2055-66. (SCI. IF= 4.814)

Review articles

1. C.H. Lin, H.Y. Li, Y.C. Lee, M.J Calkins, K.H. Lee, C.N. Yang, P.J. Lu*, (2014) Landscape of Pin1 in cell cycle. Journal of Experimental Biology and Medicine. (Accepted)

指導學生:

博士班學生:許哲裕(基醫所)、許太乙(基醫所)、賈書悌(臨醫所)

            王柏舜(臨醫所)、蔡承勳(基醫所)、李豪嶧(臨醫所)

98畢:李崑豪(基醫所)

99畢:許凱熙(臨醫所)

100畢:張光裕(臨醫所)

101畢:李育誠(基醫所)

103畢:林逢嘉(臨醫所)、林仁泰(臨醫所)

 

碩士班學生:周承翰(臨醫所)

98畢:鄭惠娟(臨醫所) 

99畢:郭勁宏(臨醫所)、陸致信(微免所)

100畢:葉清彤(臨醫所)

101畢:郭佩芳(臨醫所)

102畢:洪琬珺(臨醫所)