My laboratory has been focused on doing medical research regarding human immunological and infectious diseases with the goal of achieving improved clinical treatment based on scientific insights. His laboratory research contributed to the understanding of the mechanisms underlying human primary and secondary immunodeficiency diseases and how subtle immunodeficiencies lead to different infections. The recent results from his laboratory addressed the question how metabolic programming in immune cells changes the host defense and how reactive oxygen species affect immune responses mediated by innate and acquired immune cells. His clinical research work focuses on the treatment pediatric patients with immunodeficiencies, autoimmune diseases, cancers and allergy and how these patients respond to infections and vaccinations
1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
1998.08~2009.07 Assistant Professor, Associate Professor, Professor/ Department of Microbiology and Immunology, NCKU
2009.08~Present Professor/Institute of Clinical Medicine
2010.08~2023.07 Editor/ Journal of Microbiology, Immunology and Infection
2011.08~2017.07 Chair/ Graduate institute of clinical medicine NCKU/
2016.08~2019.08 Distinguished Professor
2017.10~ Researcher/ National Laboratory Animal Center
2023.08~ Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
1.The Pivotal Role of SLC5A6 Vitamin Transporter on B Cell Repertoire Formation via Germinal Center-dependent and – independent Pathways and its Impact on Vaccine Response. (2024/8/1~2027/7/31) –NSTC
2.Longitudinal investigation on the responses to different vaccines in acute lymphoblastic leukemia children who receive maintenance therapy or completed the chemotherapy. (113 Research Center for Pandemic Prevention Science Program) (2024/3/1~2025/2/28)- NSTC
3.Functional and genetic analyses of host responses to SARS-CoV-2 vaccination and infection in children, a multi-center cooperative study. (112 Research Center for Pandemic Prevention Science Program) (2023/03/01~ 2024/02/29)- NSTC
4.Functional and genetic analyses of host responses to SARS-CoV-2 vaccination and infection in children, a multi-center cooperative study (111 Research Center for Pandemic Prevention Science Program) (2022/03/01~ 2023/02/28)- MOST
5.Innate Lymphoid Cell Transdifferentiation: The Critical Turning Point from Allergic Inflammation to Pulmonary Fibrosis (2022/08/01~ 2025/07/31)- MOST
6.The effects of metabolic modular switching on antibody production and immune responses to vaccines (2021/08/01~ 2022/07/31)- MOST
7.2021 UMP-NCKU Joint Research Program (5)- Comparison of epidemiological features of seafood allergy between Taiwan and Vietnam (2021/01/01~ 2021/12/31)- NCKU
8.A comprehensive international investigation on the innate and adaptive immune responses in patients with COVID-19 in acute and recovering clinical stage (2020/06/01 ～ 2021/05/31)- MOST
9.The immune cell metabolic reprogramming and the terminal differentiation of plasma cells (2020/08/01 ～ 2021/07/31)- MOST
10.Treatment of Inflammatory Arthritis by Modulating the Redox Homeostasis in Joints (2017/08/01 ～ 2020/07/31)- MOST
11.The role of leukocyte-produced oxidant stress in tissue inflammation and early immune development in the lung (2020/01/01~ 2020/12/31)- NCKUH
