Kuen-Jer Tsai – 國立成功大學-臨床醫學研究所

faculty

Distinguished Professor

Kuen-Jer Tsai

Extension:

06-235-3535 ext.4254

Laboratory:

NCKU Hospital Outpatient Building 7F-7057

Email：

kjtsai@mail.ncku.edu.tw

Research Expertise:

Neurodegenerative diseases, Dementia, Alzheimer’s disease, FTLD, Stroke, Brain injury, Stem cell, Drug treatment, Cell therapy, Nucleic acid therapy, Disease animal models

Highest educational qualification:

PhD, Institute of Life Sciences, National Defense Medical Center/Academia Sinica

The major research of our laboratory is focused on dementia associated neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobe degeneration, ischemic stroke, subarachnoid hemorrhage, brain trauma, etc. We integrate concepts and techniques in molecular biology, cell biology, biochemical analysis, imaging techniques, and neurobiology, aiming to verify experimental hypotheses and clarify the functional characterization and physiological mechanisms with disease animal models and patients. The accomplishment of exploring the pathogenesis of dementia and developing new treatment strategies can shed further light on the purpose of translational medicine.

2011 Y. Z. Hsu Scientific Paper Award
2012 National Cheng Kung University Paper Award
2012 CHENG-HSING Medical Foundation Paper Award
2014 CHENG-HSING Medical Foundation Paper Award
2017 CHENG-HSING Medical Foundation Paper Award
2018 CHENG-HSING Medical Foundation Paper Award
2019 CHENG-HSING Medical Foundation Paper Award
2020 CHENG-HSING Medical Foundation Paper Award
2021 CHENG-HSING Medical Foundation Paper Award
2022 CHENG-HSING Medical Foundation Paper Award
2022 National Innovation Award
2023 CHENG-HSING Medical Foundation Paper Award
2023 Outstanding Research Award in Basic Medicine in College of Medicine, NCKU
2024 CHENG-HSING Medical Foundation Paper Award
2025 CHENG-HSING Medical Foundation Paper Award
2025 NSTC Future Tech Award
2025 National Innovation Award

2021.08~Present Distinguished Professor, Institute of Clinical Medicine, NCKU
2017.08~Present Vice Director, Research Center of Clinical Medicine, National Cheng Kung University Hospital
2017.08~2021.07 Professor, Institute of Clinical Medicine, NCKU
2012.08~2017.07 Associate Professor, Institute of Clinical Medicine, NCKU
2010.02~2012.07 Assistant Professor, Institute of Clinical Medicine, NCKU
2002.04~2009.02 Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan

Kuo J.H., Chuang M.S., Jan H.C., Ho Y.H., Kao Y.L., Tsai K.J.*, Ou Y.C.* (2025). Predicting Initial Trial Without Catheter Failure After Prostate Deobstruction Surgery Using Preoperative Urodynamics. Int Neurourol J. 2025 Nov 4.
Ling T.C., Chang C.C., Wu J.L., Lin W.R., Sun C.Y., Huang C.H., Tsai K.J., Chang Y.T. (2025). Development of Machine-Learning-Based Models for Detection of Cognitive Impairment in Patients Receiving Maintenance Hemodialysis. Eur J Neurol. 2025 Jun;32(6):e70246.
Pang Y.L., Fang S.Y., Huang C.C., Lin M.W., Roan J.N., Tsai K.J., Lam C.F.* (2025). TRANSPLANTATION OF VIABLE ALLOGENEIC MITOCHONDRIA PROTECTS KIDNEY FUNCTION IN A MOUSE MODEL OF HEMORRHAGIC SHOCK AND RHABDOMYOLYSIS-INDUCED ACUTE RENAL INJURY. Shock. 2025 Jun 1;63(6):929-934.
Ho P.C., Hsieh T.C., Tsai K.J.* (2024). TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: From pathomechanisms to therapeutic strategies. Ageing Res Rev. 2024 Jul 27;100:102441.
Lee H.W., Chen S.J., Tsai K.J., Hsu K.S., Chen Y.F., Chang C.H., Lin H.H., Hsueh W.Y., Hsieh H.P., Lee Y.F., Chiang H.C., Chang J.Y.* (2024). Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function. J Biomed Sci. 2024 May 9;31(1):46.
Hung J.H., Tsai P.H., Aala W.J.F., Chen C.C., Chiou S.H., Wong T.W., Tsai K.J., Hsu S.M.*, Wu L.W.* (2024). TIMP3/Wnt axis regulates gliosis of Müller glia. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167087.
Fang Y.H., Wang S.P.H., Liao I.C., Tsai K.J., Huang P.H., Yang P.J., Yen C.J., Liu P.Y., Shan Y.S., Liu Y.W.* (2023). HLA-Ehigh /HLA-Ghigh /HLA-IIlow Human iPSC-Derived Cardiomyocytes Exhibit Low Immunogenicity for Heart Regeneration. Advanced Healthcare Materials. 2023 Nov;12(29):e2301186.
Chu Y.P., Ho P.C., Tsai K.J.* (2023). TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy. Autophagy. 19(8):2403-2405.
Abijo A., Lee C.Y., Huang C.Y., Ho P.C., Tsai K.J.* (2023). The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases. Biomedicines. 26;11(7):1828.
Hsu Y.T., Chen L.H., Liu Y.H., Chu S.K., Chen T.Y., Tsai K.J., Shen M.R.*, Liu W.* (2023). Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy. Small Methods. 2023 Jun;7(6):e2201300.
Chu Y.P., Jin L.W., Wang L.C., Ho P.C., Wei W.Y., Tsai K.J.* (2023). Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP. Brain. 2;146(5):2089-2106.
Ou Y.C., Huang C.C., Kao Y.L., Ho P.C., Tsai K.J.* (2023). Stem Cell Therapy in Spinal Cord Injury-Induced Neurogenic Lower Urinary Tract Dysfunction. Stem Cell Reviews and Reports. 19, 1691–1708.
Kao Y.L., Ou Y.C., Tsai K.J., Kuo H.C.* (2022). Predictive Factors for a Successful Treatment Outcome in Patients with Different Voiding Dysfunction Subtypes Who Received Urethral Sphincter Botulinum Injection. Toxins. 2022; 14(12):877.
Wang I.F., Ho P.C., Tsai K.J.* (2022). MicroRNAs in Learning and Memory and Their Impact on Alzheimer’s Disease. Biomedicines, 10(8):1856.
Jan M.W., Chiu C.Y., Chen J.J., Chang T.H., Tsai K.J.* (2022). Human Platelet Lysate Induces Antiviral Responses against Parechovirus A3. Viruses-Basel, 14(7):1499.
Wong C.E., Chu Y.P., Tsai K.J.* (2022). Structure-Based Analysis of Protein Cluster Size for Super-Resolution Microscopy in the Nervous System. Biomedicines, 27;10(2):295.
Jan M.W., Su H.L., Chang T.H., Tsai K.J.* (2021). Characterization of Pathogenesis and Inflammatory Responses to Experimental Parechovirus Encephalitis. Frontiers in Immunology, 5013.
Wang L.C.*, Wei W.Y., Ho P.C., Wu P.Y., Chu Y.P., Tsai K.J.* (2021). Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain. Frontiers in Aging Neuroscience, 13:741168.
Ling T.C., Chang C.C., Li C.Y., Sung J.M., Sun C.Y., Tsai K.J., Cheng Y.Y., Wu J.L., Kuo Y.T., Chang Y.T.* (2021). Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study. European Journal of Neurology, 2021 Sep 24.
Sung P.S., Lee K.P., Lin P.Y., Su H.C., Yu R.L., Tsai K.J., Lin S.H., Chen C.H.* (2021). Factors Associated with Cognitive Outcomes After First-Ever Ischemic Stroke: The Impact of Small Vessel Disease Burden and Neurodegeneration. Journal of Alzheimer’s Disease, 83(2):569-579.
Sung P.S., Chen P.W., Yen C.J., Shen M.R., Chen C.H., Tsai K.J.*, Lin C.K.* (2021). Memantine Protects against Paclitaxel-Induced Cognitive Impairment through Modulation of Neurogenesis and Inflammation in Mice. Cancers (Basel), 19;13(16):4177.
Wang I.F., Wang Y.H., Yang Y.H., Huang G.J., Tsai K.J.*, Shen C.K.J.* (2021). Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability. Cell Reports, 36(5):109477.
Hung P.H., Yeh C.C., Hsiao C.Y., Muo C.H., Hung K.Y., Tsai K.J.* (2021). Erythropoietin Use and the Risk of Stroke in Patients on Hemodialysis: A Retrospective Cohort Study in Taiwan. Journal of the American Heart Association, e019529.
Ou Y.C., Huang K.H., Jan H.C., Kuo H.C., Kao Y.L., Tsai K.J.* (2021). Therapeutic Efficacy of Urethral Sphincteric Botulinum Toxin Injections for Female Sphincter Dysfunctions and a Search for Predictive Factors. Toxins (Basel), 2;13(6):398.
Wong C.E., Jin L.W., Chu Y.P., Wei W.Y., Ho P.C., Tsai K.J.* (2021) TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism. Theranostics, 11(1): 330-345.
Chuang H.C., Tsai K.L., Tsai K.J., Tu T.Y., Shyong Y.J., Jou I.M., Hsu C.C., Shih S.S., Liu Y.F., Lin C.L.* (2020). Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways. Aging-US, 2020 Nov 20;12.
Chen, P.C., Hsueh, Y.W., Lee, Y.H., Tsai, H.W., Tsai K.J., Chiang, P.M.* (2020). FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK. Cellular and Molecular Life Sciences, 78, 2199;212.
Su I.J., Chang H.Y., Wang H.C., Tsai K.J.* (2020) A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer’s Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. International Journal of Molecular Sciences, 30;21(15):5459.
Wu C.C., Jin L.W., Wang I.F., Wei W.Y., Ho P.C., Liu Y.C., Tsai K.J.* (2020) HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies. EMBO Molecular Medicine, 12(6):e10622.
Kao Y.C., Ho P.C., Tu Y.K., Jou I.M., Tsai K.J.* (2020) Lipids and Alzheimer’s Disease. International Journal of Molecular Sciences, 21, 4, 1505.
Yoshihito H, Lin H.T., Lee C.C., Tsai K.J.* (2020) Effects of Neural stem cell transplantation in Alzheimer’s disease models. Journal of Biomedical Science, 27, 29.
Sung P.S., Lin P.Y., Liu C.H., Su H.C., Tsai K.J.* (2020) Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches. International Journal of Molecular Sciences, 21(3):701.
Lee T.L., Liu C.H., Chang Y.M., Lin T.Y., Chien C.Y., Chen C.H., Tsai K.J., Lin S.H., Sung P.S.* (2020) The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer’s Disease. Journal of Alzheimer’s Disease, doi: 10.3233/JAD-190762.
Kao Y.C., Wei W.Y., Wang L.C.*, Tsai K.J.* (2019) High Fat Diet Suppresses Peroxisome Proliferator-activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International Journal of Molecular Sciences, 21(1):207.
Hung P.H., Yeh C.C., Sung F.C., Hsiao C.Y., Muo C.H., Hung K.Y., Tsai K.J.* (2019) Erythropoietin prevents dementia in hemodialysis patients. Aging-US, 11(17):6941-6950.
Liao H.W., Huang T.H., Chang Y.H., Liou H.H., Chou Y.H., Sue Y.M., Hung P.H., Chang Y.T., Ho P.C., Tsai K.J.* (2019) Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production. International Journal of Molecular Sciences, 20(8): 2044.
Pai M.C., Kuo Y.M., Wang I.F., Chiang P.M., Tsai K.J.* (2019) The role of methylated circulating nucleic acids as a potential biomarker in Alzheimer’s disease. Molecular Neurobiology, 56(4):2440-2449.
Wu C.C., Wang L.C., Su Y.T., Wei W.Y., Tsai K.J.* (2018) Synthetic α5β1 Integrin Ligand PHSRN is Proangiogenic and Neuroprotective in Cerebral Ischemic Stroke. Biomaterials, 185:142-154.
Kao Y.C., Wang I.F., Tsai K.J.* (2018). miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline. International Journal of Molecular Sciences, 19(8):2323.
Hung C.L., Yeh C.C., Sung P.S., Hung C.J., Muo C.H., Sung F.C., Jou I.M., Tsai K.J.* (2018) Is Partial or Total Thyroidectomy Associated with Risk of Long-Term Osteoporosis. World Journal of Surgery, doi: 10.1007/s00268-018-4573-2.
Wu C.C., Wang I.F., Chiang P.M., Wang L.C., Shen C.J., Tsai K.J.* (2017) G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis. Molecular Neurobiology, 54(8):6198-6212.
Wang L.C., Wu C.L., Cheng Y.Y., Tsai K.J.* (2017). Deletion of nuclear localizing signal attenuates pro-inflammatory activity of Prothymosin-alpha and enhances its neuroprotective effect on transient ischemic stroke. Molecular Neurobiology, 54(1):582-593.
Hung P.H., Yeh C.C., Hsiao C.Y., Sung P.S., Muo C.H., Sung F.C., Hung K.Y., Tsai K.J.* (2017) End stage renal disease is associated with development of dementia. Oncotarget, 8(64):107348-107355.
Sung P.S., Yeh C.C., Wang L.C., Hung P.H., Muo C.H., Sung F.C., Chen C.H., Tsai K.J.* (2017) Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder. Current Alzheimer Research, 14(3):309-316.
Lee Y.H., Hsueh Y.W., Peng Y.H., Chang K.C., Tsai K.J., Sun H.S., Su I.J., Chiang P.M.* (2017) Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium. BMC Biology, 15(1):22.
Wu P.T., Kuo L.C., Su F.C., Chen S.Y., Hsu T.I., Li C.Y., Tsai K.J.*, Jou I.M.* (2017). High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy. Scientific Reports, 2017 7:40840.
Tsai K.J., Sze C.I., Lin Y.C., Lin Y.J., Hsieh T.H., Lin C.H.* (2016, Oct). A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life. PLoS One, 11(10):e0165752.
Wu C.C., Lien C.C., Hou W.H., Chiang P.M., Tsai K.J.* (2016) Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease. Scientific Report, 6:27358.
Wang L.C., Wu C.L., Cheng Y.Y., Tsai K.J.* (2016) Deletion of nuclear localizing signal attenuates pro-inflammatory activity of Prothymosin-alpha and enhances its neuroprotective effect on transient ischemic stroke. Molecular Neurobiology, 2016 Jan.
Huang C.Y., Wang L.C., Wang H.K., Pan C.H., Cheng Y.Y., Shan Y.S., Chio C.C., Tsai K.J.* (2015) Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage. Molecular Neurobiology, 51(3):1038-1052.
Wu M.H., Huang C.C., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Lin M.T.* (2015) Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. Molecular Neurobiology, 2015 Sep 15.
Wu M.H., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Huang C.C., Lin M.T. (2015) Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis. Molecular Neurobiology, 2015 Jul 1.
Wang H.K., Lee Y.C., Huang C.Y., Liliang P.C., Lu K., Chen H.J., Li Y.C., Tsai K.J.* (2015) Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis. Neurosciences, 300, 94-103.
Liao H.W., Hung P.H., Hsiao C.Y., Liou H.H., Lin H.S., Huang T.H., Jou I.M., Tsai K.J.* (2015) Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy. PLoS One, 10(7):e0133278.
Wu Y.T., Yu I.S., Tsai K.J., Shih C.Y., Hwang S.M., Su I.J., Chiang P.M.* (2015) Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system. Scientific Report, 5:9718
Huang C.Y., Li Y.C., Wang H.K., Sung P.S., Wang L.C., Sun Y.T., Pan C.H., Tsai K.J.* (2015) Stroke suggests increased risk of dementia. Current Alzheimer Research, 12(3):287-295.
Wang I.F., Tsai K.J.*, Shen C.K.* (2015) Spermidine on neurodegenerative diseases. Cell Cycle, 14(5):697-698.
Fang Y.S., Tsai K.J., Chang Y.J., Kao P., Woods R., Kuo P.H., Wu C.C., Liao J.Y., Chou S.C., Lin V., Jin L.W., Yuan H., Cheng I., Tu P.H., Chen Y.R.* (2014) Full-Length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients. Nature Communications, 5:4284.
Huang L.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Prevalence, incidence, and comorbidity of clinically diagnosed obsessive-compulsive disorder in Taiwan: A national population-based study. Psychiatry Research, 2014 Aug 15. pii: S0165-1781.
Lu K., Wang H.K., Yeh C.C., Huang C.Y., Sung P.S., Wang L.C., Muo C.H., Sung F.C., Chen H.J., Li Y.C., Chang L.C., Tsai K.J.* (2014) Association between Autoimmune Rheumatic Diseases and the Risk of Dementia. BioMed Research International, 2014:861812.
Hung P.H., Huang Y.T., Hsiao C.Y., Sung P.S., Guo H.R., Tsai K.J.* (2014) Young stroke patients are at high risk for subsequent end-stage renal disease: a population-based observational study. Nephrology Dialysis Transplantation, 29(4):873-878.
Wang H.K., Tsai K.J., Huang C.Y., Wang L.C., Lu K., Chen H.J., Lin C.W., Lee Y.J., Fang P.H., Chang L.C., Li Y.C.* (2014) Newly diagnosed dementia and increased risk of hemorrhagic stroke: A nationwide population-based study. Current Alzheimer Research, 11(3):291-298.
Shih Y.H., Tsai K.J., Lee C.W., Shiesh S.C., Chen W.T., Pai M.C., Kuo Y.M.* (2014) Apolipoprotein C-III is an Amyloid-β-Binding Protein and an Early Marker for Alzheimer’s Disease. Journal of Alzheimer’s Disease, 41(3):855-865.
Tsai M.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. Journal of Pediatrics, 164(1):136-141.
Liu Y.C., Chiang P.M., Tsai K.J.* (2013) Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications. International Journal of Molecular Sciences, 14(10): 20079-20111.
Jou I.M., Lin C.F., Tsai K.J.* Wei S.J. (2013) Macrophage-mediated inflammatory disorders. Mediators of Inflammation, 2013: 316482.
Lee Y.S., Chio C.C., Chang C.P., Wang L.C., Niu K.C., and Tsai K.J.* (2013) Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke. Mediators of Inflammation, 2013:512978.
Wang I.F., Tsai K.J.* and Shen C.K.* (2013) Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: A new light for treatment of TARDBP/TDP-43 proteinopathies. Autophagy, 9(2):239-240.
Wang H.K., Lin S.H., Sung P.S., Wu M.H., Hung K.W., Wang L.C., Huang C.Y., Lu K., Chen H.J., and Tsai K.J.* (2012) Population-based study on patients with traumatic brain injury suggests increased risk of dementia. Journal of Neurology, Neurosurgery, and Psychiatry 83(11):1080-1085.
Wang L.C., Chang C.P., Chio C.C., Wu M.H., Lee Y.S., Huang C.Y., Tsai K.J.* (2012) Hypobaric hypoxia preconditioning attenuates experimental heatstroke syndromes via preinduction of heat shock protein 70. The American Journal of the Medical Sciences, 344(5):383-390.
Wang I.F., Guo B.S., Liu Y.C., Wu C.C., Yang C.H., Tsai K.J.*, Shen C.K.J.* (2012) Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proceedings of the National Academy of Science USA, 109(37):15024-15029.
Majumder P., Chen Y.T., Bose J.K., Wu C.C., Cheng W.C., Cheng S.J., Fang Y.H., Chen Y.L., Tsai K.J., Lien C.C., Shen C.K.J.* (2012) TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta Neuropathologica, 124(2):231-245.
Lin K.C., Niu K.C., Tsai K.J., Kuo J.R., Wang L.C., Chio C.C.*, and Chang C.P.* (2012) Attenuating inflammation but stimulating both angiogenesis and neurogenesis by hyperbaric oxygen in rats with traumatic brain injury. Journal of Trauma, Injury, Infection, and Critical Care, 72(3):650-659.
Wang L.C., Huang C.Y., Wang H.K., Wu M.H., and Tsai K.J.* (2012) Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. Journal of Neurotrauma, 29(7):1518-1529.
Tsai K.J., Yang C.H., Fang Y.H., Cho K.H., Chien W.L., Wang W.T., Wu T.W., Lin C.P., Fu W.M., and Shen C.K.J.* (2010) Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. Journal of Experimental Medicine, 207:1661-1673.
Tsai K.J., Yang C.H., Lee P.C., Wang W.T., Chiu M.J., and Shen C.K.J.* (2009) Asymmetric expression patterns of transthyretin transcripts in normal and a transgenic mouse model of Alzheimer’s disease. Neuroscience, 159:638-646.
Tsai K.J., Tsai Y.C. and Shen C.K.J.* (2007) G-CSF rescues the memory impairment of animal models of Alzheimer’s disease. Journal of Experimental Medicine, 204:1273-1280.
Tsai K.J., Chen S.K., Ma Y.L., Hsu W.L., and Lee E.H.Y.* (2002) Sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proceedings of the National Academy of Science USA, 99:3990-3995.
Lee E.H.Y.*, Hsieh Y.P., Yang C.L., Tsai K.J. and Liu C.H. (2000) Induction of integrin-associated protein (IAP) mRNA expression during memory consolidation in rat hippocampus. European Journal of Neuroscience, 12:1105-1112.
Lee H.M.*, Tsai K.J., Lin C.H., Huang C.L. and Tung C.S. (1998) Arecoline desensitizes carbachol-stimulated phosphatidylinositol breakdown in rat brain cortices. Journal of Neurochemistry, 70:1189-1198.