國立成功大學-臨床醫學研究所

2016 Outstanding Publication in International Top Journals Award, NCKU
2018 Japanese Society of Investigative Dermatology Travel Fellowship Award

2011-2012 Postdoctoral Fellow / Department of Pathology, USC
2012 Oct. ~2015 Jan.
Vice Director of Research & Principle Investigator / Research Center of Wound Regeneration & Repair (iWRR), NCKU
Assistant Professor / Institute of Clinical Medicine, NCKU
2015 Jan. ~2023 Jul.
Assistant Professor / Institute of Clinical Medicine, NCKU
2023 Jul. ~Present
Associate Professor / Institute of Clinical Medicine, NCKU

1. Chen-Yi Su, Tzu-Yu Liu, Hao-Ven Wang, Michael W. Hughes, Cheng-Ming Chuong, Wei-Cheng Yang (2025, Jan). Histological characterization of γδ T cells in cutaneous wound healing in Fraser’s dolphins (Lagenodelphis hosei). Developmental and Comparative Immunology, 163(2025)105326.
2. Wan-Yu Chi, Hao-Wei Huang, Gang-Hui Lee, Criselda Jean G. Cruz), Michael W. Hughes, Ming-Jer Tang, Shyh-Jou Shieh, Chao-Chun Yang (2024, Dec). Mechanical stiffness across skin layers in human: a pilot study. Tissue Barriers.
3. Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael W. Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang, Po-Hsien Huang (2024, Feb). Stromal Rigidity Stress Accelerates Pancreatic Intraepithelial Neoplasia Progression and Chromosomal Instability via Nuclear Protein Tyrosine Kinase 2 Localization. The American Journal of Pathology, 194(7):1346-1373. 
4. Chu-Han Hsieh, Ju Lee, Hsiang-Hsuan Sung, Ya-Fang Huang, Yu-Sian Ding, Chia-Yi Li, Chia-Liang Yen, Chao-Kai Hsu, Chun-Keung Yu, Hsin-Ying Hsieh , Michael Warren Hughes, Peng-Chieh Chen, Chi-Chang Shieh (2023, Nov). Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment. Clinical Immunology, 257.
5. Hsueh-Chien Chiang, Michael Hughes, Wei-Lun Chang (2023, Oct). The role of microbiota in esophageal squamous cell carcinoma: A review of the literature. Thorac Cancer, 14(28):2821-2829. 
6. Tzu-Yu Liu, Michael W. Hughes, Hao-Ven Wang, Wei-Cheng Yang, Cheng-Ming Chuong, Ping Wu (2023, Jul). Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo-Devo Novelty of Skin Appendages in Foot Sole.. Journal of Development Biology, 11(3), 30.
7. Hans I-Chen Harn, Po-Yuan Chiu, Chein-Hong Lin, Hung-Yang Chen, Yung-Chih Lai, Fu-Shiuan Yang, Chia-Ching Wu, Ming-Jer Tang, Cheng-Ming Chuong, Michael W Hughes (2022, Sep). Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis. Pharmaceutics. 
8. Chen-Yi Su, Hao-Ven Wang, Michael W Hughes, Tzu-Yu Liu, Cheng-Ming Chuong, Wei-Cheng Yang (2022, Jun). Successful Repigmentation of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei). Animals (Basel). 
9. Su CY, Hughes MW, Liu TY, Chuong CM, Wang HV, Yang WC. (2022, Feb). Defining Wound Healing Progression in Cetacean Skin: Characteristics of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei). Animals (Basel), 12(5):537.
10. Hans I.Chen Harn, Sheng Pei Wang, Yung Chih Lai, Ben Van Handel, Ya Chen Liang, Stephanie Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, Stefan Kaemmer, Ming Jer Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting Xin Jiang, Cheng Ming Chuong (2021, May). Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nature communications, 12(1):2595. 
11. Wei-Ting Chang, Michael W. Hughes, Ping-Yen Liu (2020, Aug). The impact of COVID-19 on the research and educational environment in Taiwan –Forewarned is forearmed . Journal of the Formosan Medical Association. 
12. Michael W. Hughes, Ping-Yen Liu (2020, Jul). An American’s perspective living through COVID-19 in Taiwan. Journal of the Formosan Medical Association. 
13. Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang, Pei-Jung Lu, Yan-Shen Shan & Po-Hsien Huang (2020, Jun). Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. Clinical Epigenetics, 12(1):87. 
14. Lin CH, Chiu PY, Hsieh YY, Shieh SJ, Wu CC, Wong TW, Chuong CM, and Hughes MW (2019, Jan). Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol.. 
15. Hsu CK, Lin HH, Harn HI, Hughes MW, Tang MJ, and Yang CC (2018, Jun). Mechanical forces in skin disorders.. J of Dermatol Sci. 
16. Michael W. Hughes, Ting-Xin Jiang, Maksim V. Plikus, Christian Fernando Guerrero- Juarez, Chein-Hong Lin, Christopher Schafer, Robert Maxson, Randall B. Widelitz, Cheng-Ming Chuong (2018, Feb). Msx2 supports epidermal competency during wound induced hair follicle neogenesis. The Journal of Investigative Dermatology, 138: 2041-2050. (SCI). MOST 107-2314-B-006-080. 本人為第一作者. 
17. Wong TW, Hughes M, Wang SH. (2018, Jan). Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient.. Journal of Tissue Viability, 27(2):114-116. 
18. Hans I-Chen Harn, Rei Ogawa, Chao-Kai Hsu, Michael W Hughes, Ming-Jer Tang, Cheng-Ming Chuong (2017, Nov). The tension biology of wound healing. Experimental Dermatology, 28(4):464-471. 
19. Chin-Fu Huang1,* , Ya-Ju Chang2,* , Yuan-Yu Hsueh3, Chia-Wei Huang2, Duo-HsiangWang3, Tzu-Chieh Huang2, Yi-TingWu3,4, Fong-Chin Su1, Michael Hughes5,6, Cheng-MingChuong5,6,7 & Chia-ChingWu1,2,4,5 (2016, May). Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction.. Nature Scientific Report. 
20. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez FC, Hughes MW, Jiang TX, Lee OK, Shi S, Widelitz R, Lander AD, Chuong CM. (2015, Apr). Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations. Cell, 161(2):277-90. 
21. CC Yang, HM Sheu, PL Chung, CH Chang, YS Tsai, MW Hughes, TL Tuan, LH Huang. (2015, Jan). Leptin of skin adipose tissue is differentially expressed during hair cycle and attributes partially to adipocyte-mediated growth inhibition of anagen phase vibrissa hair.. Experimental Dermatology, 24(1):57-60. 
22. CK Hsu, SY Tzeng, J Lee, L Huang, WR Chen, MW Hughes, YW Chen, YK Liao, SH Tseng. (2015, Jan). Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy.. Biomedical Optics Express, 6(2):390-404. 
23. KW Chang, AT Huang, IH Liu, Yi-Hui Wang, P Wu, YT Tseng, MW Hughes, TX Jiang, MH Tsai, CY Chen, YJ Oyang, EC Lin, CM Chuong, SP Lin (2015, Jan). Emergence of differentially regulated pathways associated with the development of regional specificity in the chicken skin.. BMC Genomics. 
24. Hughes MW, Jiang TX, Lin SJ, Lueng Y, Kobielak K, Widelitz R, and Chuong CM (2014, Jan). Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1,2 deletion in the epidermis. Journal of Investigative Dermatology, 134(1):24-32. 
25. Hughes MW, Lu W, and Chuong CM (2013, Sep). Nuclear topology, epigenetics, and keratinocyte differentiation.. Journal of Investigative Dermatology, 133(9):2130-3. 
26. Chueh SC, Chen CC, Hughes MW, Jiang TX, Lei M, Lin SJ, Widelitz R, and Chuong CM. (2013, Mar). Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opinion on Biological Therapy, 13(3):377-91. 
27. Li J, Jiang TX, Hughes MW, Wu P, Widelitz R, Guoping F, and Chuong CM. (2012, Dec). Progressive alopecia reveals decreasing stem cell activation probablity during againg of mice with epidermal deletion of dna methylatransferase 1.. Journal of Investigative Dermatology, 132(12):2681-90. 
28. Leto Barone AA1, Zhou ZY, Hughes MW, Park R, Schulman RM, Lee S, Vidar EN, Shiba TL, Weber EL, Cetrulo CL Jr. (2012, Feb). LENTIVIRAL TRANSDUCTION OF FACE AND LIMB FLAPS: IMPLICATIONS FOR IMMUNOMODULATION OF VASCULARIZED COMPOSITE ALLOGRAFTS. Plastic and Reconstructive Surgery, 129(2):391-400. 
29. Hughes M, Wu P, Jiang J, Lin S, Dong C, Li A, Hsieh F, Widelitz R, and Chuong C (2011, Apr). IN SEARCH OF THE GOLDEN FLEECE: UNRAVELING PRINCIPLES OF MORPHOGENESIS BY STUDYING THE INTEGRATIVE BIOLOGY OF SKIN APPENDAGES. Integrative Biology, 3: 388-407.