吳醫師是一位神經科醫師臨床專長在癲癇，研究興趣在神經調控和神經電生理學。實驗室致力於研究電刺激如何影響大腦功能與其神經生理機制，並探索電神經調控在異常興奮性和神經迴路失調為基礎的神經精神疾病之潛在治療契機。
台灣癲癇學會癲癇研究論文獎第一名(2025)
台灣癲癇學會癲癇研究論文獎佳作(2022)
成杏優秀論文獎(Top 10% paper, 2022)
全國兒童神經精神科學勵翔獎臨床組第一名(2022)
國立成功大學醫學院2021年新人最佳論文獎(2021)
台灣癲癇學會癲癇研究論文獎佳作(2021)
臺灣綜合大學系統年輕學者創新研發成果選拔佳作獎(2021)
科技部優秀年輕學者研究計畫(2019-2022)
台灣癲癇學會癲癇研究論文獎佳作(2020)
成大醫學院教學創新團體佳作(109學年度)
成杏優秀論文獎(2018)
成大醫學院博士論文競賽優勝(2017)
中華民國斐陶斐榮譽學會榮譽會員
成大醫院醫療科技研究計畫成果競賽獎(2015年基礎臨床組第二名, 2016年基礎臨床組第一名)
中央研究院跨領域神經科學暨國際研究生博士班學程出席國際會議壁報論文競賽獎
台灣神經醫學聯合學術研討會優秀壁報論文獎(2010年, 2012年, 2013年, 2015年, 2016年)
高雄醫學大學年度最佳實習醫師獎
國立台灣大學書卷獎
國立成功大學醫學院臨床醫學研究所助理教授，副教授(現職)
國立成功大學醫學院神經學科臨床助理教授
國立成功大學附設醫院神經部住院醫師，總醫師，臨床研究員，主治醫師(現職)
國立成功大學附設醫院斗六分院神經科主治醫師
國立中央大學認知神經科學研究所訪問研究員
英國倫敦大學神經學院訪問研究員
美國凱斯西儲大學訪問研究學者
Publications (*corresponding author)
- PH Wu, ME Chien, YJ Wu*, CH Fan*. Focused ultrasound combined with drug-loaded microbubbles suppresses ictal spikes in kainic acid-induced epileptic animals. Ultrasonics Sonochemistry 2025; 120:107518. (IF 9.7, Acoustics 1/41, 98.8%, IF 9.7)
- CC Chiang, ME Chien, YC Huang, JT Lin, SF Liang, KS Hsu, DM Durand*, and YJ Wu*. Cathodal weak direct current decreases epileptic excitability through reducing neuronal activity and enhancing delta oscillations. Journal of Physiology 2025; 603(9):2763-2782. (IF 4.4, 89.1% in Physiology)
- PY Lin, CT Hsiao, HW Huang, YJ Wu, SJ Fu, YC Lee*. Intrafamilial Phenotypic Variation in Taiwanese Patients with Hereditary Spastic Paraplegia and Charcot-Marie-Tooth Disease Due to KIF5A Mutations: A Cross-Sectional Observational Study. Acta Neurol Taiwan 2025 Jun 11. Online ahead of print.
- YC Hung, YJ Wu, ME Chien, YT Lin, CF Tsai, KS Hsu*. Loss of oxytocin receptors in hilar mossy cells impairs social discrimination. Neurobiology of Disease 2023;187:106311.
- YT Fang†, YT Lin†, WL Tseng, P Tseng, GL Hua, YJ Chao, YJ Wu*. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications. Frontiers in Aging Neuroscience 2023;15:1173987.
- CH Chen, TC Tsai, YJ Wu, KS Hsu*. Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice. JCI Insight 2023;8(22):e161874.
- TH Yu, YJ Wu, ME Chien, KS Hsu*. Multisession anodal transcranial direct current stimulation enhances adult hippocampal neurogenesis and context discrimination in mice. Journal of Neuroscience 2023;43(4):635-646.
- YT Fang, TL Lee, YH Tu, SH Lin, ME Chien, CW Huang, KS Hsu, YJ Wu*. Factors associated with mortality in patients with super-refractory status epilepticus. Scientific Reports 2022;12:9670.
- YJ Wu*, ME Chien, CC Chiang, YZ Huang, DM Durand, KS Hsu*. Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures. Brain Stimulation 2021;14(4): 771-779.
- YJ Wu*, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu*. Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental Neurology 2020;328:113264.
- TH Yu, YJ Wu, ME Chien, KS Hsu*. Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor. Neuropharmacology 2019;144:358-367.
- HW Huang, JJ Tsai, PF Su, YL Mau, YJ Wu, WC Wang, CC K Lin*. Cortical Excitability by Transcranial Magnetic Stimulation as Biomarkers for Seizure Controllability in Temporal Lobe Epilepsy, Neuromodulation 2020;23(3): 399-406.
- MC Lai, TY Hung, KM Lin, PS Sung, SJ Wu, CS Yang, YJ Wu, JJ Tsai, SN Wu*, CW Huang*. Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotoxicity Research 2018;34(1):1-15.
- YJ Wu, CC Lin, CM Yeh, ME Chien, MC Tsao, PT, CW Huang, KS Hsu*. Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats. Brain Stimulation, 2017;10(6):1079-1087.
- YJ Wu, P Tseng, HW Huang, JF Hu, CH Juan, KS Hsu, CC Lin*. The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre– post Sham-Controlled Study. Frontiers in Human Neuroscience 2016;10:479- 489.
- MC Lai, KM Lin, JJ Tsai, YJ Wu, CW Huang*. Dupuytren’s contracture: subacute onset after long-term antiepileptic drug use. Neuropsychiatry 2016;6(6), 366-368.
- YJ Wu, P Tseng, CF Chang, MC Pai, KS Hsu, CC Lin*, CH Juan*. Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain and Cognition 2014;91:87-94.
- YJ Wu, CC Lin*. Cold-induced eyelid myotonia. Neurology 2013;80(8):e81.
- JC Chow, CW Huang*, CW Fang, YJ Wu, JJ Tsai. Lamotrigine induced hypersensitivity syndrome in a Han Chinese patient with the HLAB*5801 genotype. Neurological Sciences 2013;34(1):117-9.
- YJ Wu, MC Pai*. Two gloves and one sock syndrome after a pontine hemorrhage. Neurologist 2012;18(4):196-8.
- YJ Wu, TT Tsai, CW Huang*. Conjugate eye deviation shifting in hemispheric stroke indicates an emerging mass effect. Journal of Clinical Neuroscience 2011;18(9):1276-8.
- CY Hsieh, NJ Chiou, YJ Wu, JJ Tsai, CW Huang*. Somatosensory rub evoked reflex epilepsy of a temporal lobe origin. Neurological Sciences 2011;32(2):297-9.
- CW Huang, YJ Wu, SN Wu*. Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience 2011;176:431-41.
- YJ Wu, MC Lai, CW Huang* (2010, Dec). Reversible postvaccination paraneoplastic encephalomyelitis in a patient with lung adenocarcinoma. International Journal of Neuroscience 2010;120(12):792-5.
- YJ Wu, JJ Tsai, CW Huang*. Nonketotic hyperglycemia-related reflex epileptic seizures induced by Mah-Jong playing. Epilepsy & Behavior, 2010;19(3):533-5.
Book Chapter
Yi-Jen Wu (2022). Electrophysiological and cellular mechanisms of transcranial direct current stimulation. In Ying-Zu Huang (1st Ed.). Noninvasive Brain Stimulation: Basic, Clinical, and Research (pp. 147-160). Taipei, Taiwan: Ho-Chi Publishing.
