沈延盛 – 國立成功大學-臨床醫學研究所

在臨床與轉譯研究方面，沈教授自 2003 年起投入上消化道癌症 (胃癌及肝膽胰癌)之系統性研究，透過跨專業整合與臨床試驗設計，建立具臨床實證基礎的治療策略，顯著改善胰臟癌患者之長期存活率。2017 年，沈教授創立「臺灣上消化道癌症臨床試驗合作聯盟（TCTC）」，整合全台 10 家醫學中心之臨床資源，推動國人自研新藥與多項化療複方之臨床驗證與國際合作，提升治療成效與研究能量。

沈教授之研究領域涵蓋腫瘤微環境、癌症抗藥性機制、癌症惡病質、奈米藥物傳遞系統及多組學整合分析，並運用大數據與人工智慧技術建立預後與治療反應之預測模型，發展具臨床可行性的個人化精準醫療策略。相關研究成果發表於《Molecular Cancer》、《Nature Communications》、《Theranostics》、《Advanced Science》等國際期刊，並獲多項傑出研究獎(徐千田臨床癌症、董大成基礎癌症、科技部傑出研究、外科高天成)與創新獎項(新創及未來科技獎)肯定。

在教育與人才培育方面，沈教授於臨床醫學研究所之教學與研究指導強調臨床問題導向與實證研究精神，培養學生與年輕醫師兼具臨床敏感度與科研能力，推動基礎研究、轉譯醫學與臨床試驗之整合，持續強化本研究所於胃腸道癌症研究領域之學術深度與國際能見度。

2025 國科會未來科技獎 (技術名稱: 多體學導引之胰臟癌精準醫療技術平台)

2025 二十二屆國家新創獎學研新創獎 (技術名稱: 針對單一胞外體檢測之免疫脂質體奈米顆粒（ILN）生物晶片暨液體活檢平台)

2025 國科會未來科技獎 (技術名稱: 通用型低免疫源性異體 iPSC 種源庫：實現再生醫療產業化與臨床突破)

2025 臺灣醫學會故高天成教授紀念演講獎

2024 國科會未來科技獎 (技術名稱: 雙靶向核酸富集胞外體生產製造與治療技術)

2024 The European Journal of Cancer (editor)

2023 Outstanding basic cancer research award,中華民國癌症醫學會董大成癌症基礎醫學傑出研究獎, Taiwan

2023 國際外科學會優秀論文金牌獎

2023 台灣特定疾病臨床試驗合作聯盟貢獻獎

2022 國際外科學會優秀論文金牌獎

2022 成功大學特聘教授

2021 成功大學李國鼎榮譽學者

2021 科技部傑出研究獎

2020 國際外科學會優秀論文金牌獎

2020 台南一中第14屆校友傑出成就獎

2019 Annual conference of American 2019 Academic Surgical Congress (ASC), Invited

Representative Speaker of Taiwan Surgery Society (AAS international guest), Houston USA (受台灣外科醫學會推薦，為美國外科醫學會受邀發表學術演講)

2019 成功大學特聘教授

2019 IGCC invited moderator, Prague, Czech Republic

2019 APHPBA Invited speaker and moderator. Seoul Korea

2019 WCGH, invited Keynote Speaker and Moderator, London UK

2018-2019 Invited speaker and moderator of TDDW, Taiwan

2017-2019 The best teacher for PGY resident in NCKUH. (成大醫院PGY最佳指導老師獎)

2017-2019 Organizer of Surgical Oncology Section in Annual Surgical Meeting

2003-2019 Speaker and moderator of Annual Meeting in Taiwan Surgical Society, Pancreas Society, Gastrointestinal Surgical Society

2018 Outstanding cancer research award,中華民國癌症醫學會徐千田傑出研究獎, Taiwan

2018 The best post award, 2018 Pancreas, Baltimore, Maryland.

2018 Post award, 中華民國癌症醫學會annual meeting, Taiwan.

2018-2023 The Best Paper Award of Cheng-Hsing Medical Foundation, Taiwan.

2018 The 2016 annual best paper of clinical medicine, College of Medicine, NCKU.

2018 Keynote Speaker, Cell Signal conference in Philadelphia, USA

2018 Invited speaker of JPS

2013-2018 成大醫院外科部研究第一名主治醫師

2017 成大醫院106年度研究傑出主治醫師

2017 The Best Paper Award of International College of Surgeons (2017), 1st.

2017 The Best Paper Award of Cheng-Hsing Medical Foundation, Taiwan.

2017 Invited speaker of Wakayama University, Japan

2016 成功大學發表國際頂尖期刊獎勵

2016 成功大學特聘教授 (2016.08.01-present)

2016 Invited speaker of IASGO, Taiwan

2016 Invited speaker of ICS Japan

2016 Invited moderator of TDDW, Taiwan

2016 Invited speaker and moderator of JPS/AOPA/APS

2016 Invited speaker of EAES

2016 Invited speaker of JPS

2015 成大醫院104年度傑出主治醫師 (Excellent visiting doctor of the year 2015, NCKUH)

2007-2015 The Annual Best Researcher of the Department of Surgery of National Cheng Kung Medical Center.

2014 Merit award of the 11th Asian Clinical Oncology Society (ACOS), Taiwan.

2014 The 51th JSSMN Travel award (instructor).

2014 The Best Paper Award of International College of Surgeons.

2012 Vedio competition Award, 2nd (runner-up), (Instructor), Ann Surg Association 2012.

2012 The Best Paper Award of International College of Surgeons (2012), 1st.

2011 Abstract award, 2nd (Runner-up) in the 9th Asia-Pacific Oncology Summit.

2011 科技部100-(2011-)年度補助大專校院獎勵特殊優秀人才措施獎勵

2010 Paper Award of International College of Surgeons (2010), 4rd. (Instructor).

2009 The 46th JSSMN Travel award (Instructor).

2009 Paper Award of International College of Surgeons (Instructor).

2008 Post of Distinction of Digestive Disease Week, USA.

2008 成功大學研究獎勵B類

2008 The Best Paper of the year of National Cheng Kung University Hospital, 2nd (Instructor).

2007 Paper Award of International College of Surgeons.

2006 The Best Oral Paper presentation (2006) of Taiwan Surgical Society Of Gastroenterology. (Instructor).

2006 Poster Award: 2004 Sendai; Joint meeting of the 11th meeting of International 2004 Association of Pancreatology and the 35th Annual meeting of the Japan Pancreas Society.

2003 The Best Paper of the year of National Cheng Kung University Hospital.

2019.08~2025.07 國立成功大學醫學院院長

2017.08~2019.07 國立成功大學臨床醫學研究所所長

2016.08~迄今國立成功大學臨床醫學研究所特聘教授

2016.08~2019.07 國立成功大學醫學院附設醫院臨床醫學研究中心主任

2012.08~2016.07 國立成功大學臨床醫學研究所教授

2010.10~2018.07 國立成功大學醫學院附設醫院上消化道癌症團隊召集人

2010.08~2012.07 國立成功大學臨床醫學研究所副教授

2008.08~ 2012.07 國立成功大學外科部副教授

2002.08~2008.07 國立成功大學外科部助理教授

1998.08~ 迄今國立成功大學醫學院附設醫院外科部主治醫師

Book

Ying-Jui Chao, Yan-Shen Shan*. Laparoscopic Pancreaticoduodenectomy. Innovation and diagnosis for pancreatic cancer. Hiroki Yamaue (ed.), Chap 10; page: 129-145. Springer Singapore 2017.

Selected Publications since 2021 (more than 280 papers, selected, * Correspondence)

Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan* and Shaw-Jenq Tsai*. Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells. Mol Cancer. 2025 Jan 18;24(1):25. (IF:33.9)
Yu-Ting Su , Yi-Cheng Tsai , Chien-Jui Huang , Nai-Jung Chiang , Anandaraju Bandaru , Shang-Cheng Hung , Yan-Shen Shan *, Gwo-Bin Lee*. Optimization of a microfluidic system for automated detection of Cholangiocarcinoma cells in bile. Biosens Bioelectron 2025 Dec 19:296:118330. doi: 10.1016/j.bios.2025.118330. (IF:10.7)
Chia-Jung Chang, Po-Hsien Huang, Szu-Ying Chen, Pei-Chia Su, Li-Yun Ding, Ya-Chin Hou, Miao-Neng Hung, Kuan-Lin Chen, Ya-Na Wu, Shang-Rung Wu, Forn-Chia Lin, Pei-Jung Lu, Hsin-Yi Wu, Yu-Ju Chen, Chih-Han Chang, Chih-Peng Chang, Daw-Yang Hwang, Yi-Ching Wang* and Yan-Shen Shan*. Macrophage activation determines muscle wasting in pancreatic cancer. Oncogene. 2025 Aug;44(32):2797-2813. (IF:7.3)
Sasi Kiran Boilla, Chien-Jui Huang, Yi-Cheng Tsai, Yan-Shen Shan*, Gwo-Bin Lee*. Effective isolation of circulating tumor cells via pearl-like, bead-chain magnetic structures on a microfluidic device. Sens Actuator B Chem. 441 (2025) 138037. (IF:7.7)
Yung-Yeh Su, Ming-Yi Lin, Siao Muk Cheng, Wei-Lun Chang, Che-Wei Hsu, C.-M. Yeh, C.-C. Yu, Ya-Chin Hou, Chien-Jui Huang, Yi-Sheng Liu, Ying-Jui Chao, Daw-Yang Hwang*, Yan-Shen Shan*, Li-Tzong Chen*. Single-cell RNA sequencing via endoscopic ultrasound-guided fine-needle biopsy for pancreatic tumors uncovered an aggressive subclone with a poor prognosis. ESMO Gastrointestinal Oncology. Volume 7, March 2025, 100113.
Wei-Hsun Lu, Ting-Kai Liao, Ping-Jui Su, Chih-Jung Wang, Ying-Jui Chao, Yan-Shen Shan*. A simple five-factor risk model for predicting new-onset diabetes after distal pancreatectomy. Am J Surg. 2025 Nov 12:251:116715. (IF:2.7)
Chrong-Reen Wang*, Hung-Wen Tsai, Wen-Chien Chou, Yan-Shen Shan. Common variable immunodeficiency with autoimmune hepatitis. J Formos Med Assoc. 2025 Nov 12:S0929-6646(25)00622-9. (IF:2.5)
Ting-Kai Liao, Wei-Hsun Lu, Ping-Jui Su, Chih-Jung Wang, Ying-Jui Chao*, Yan-Shen Shan. Comparative Analysis of Robotic Versus Laparoscopic Approaches in Minimally Invasive Spleen and Splenic Vessel Preserving Distal Pancreatectomy. ANZ J Surg. 2025 Nov;95(11):2338-2346. (IF:1.6)
Ping-Jui Su, Wei-Hsun Lu, Ting-Kai Liao, Chih-Jung Wang, Ying-Jui Chao, Yan-Shen Shan*. Outcomes of conversion surgery following chemotherapy for initially unresectable metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study in Taiwan. J Cancer Res Clin Oncol. 2025 Oct 30;151(12):308. (IF:2.8)
Wei-Hsun Lu, Ting-Kai Liao*, Che-Min Su, Tsung-Han Yang, Tsung-Ching Chou, Ping-Jui Su, Chih-Jung Wang, Ying Jui Chao, Yih-Jyh Lin, Yan-Shen Shan. Selective lymph node dissection in intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma may not impair oncological outcomes: a single-center retrospective cohort study. World J Surg Oncol. 2025 Oct 21;23(1):387. (IF:2.5)
Anjeli Manam, Jessica N Everett, Sigurdis Haraldsdottir, Phil A Hart, Vivek Kaul, Kelsey Klute, Kasmintan A Schrader, Daniel A Sussman, Bryson W Katona*; PRECEDE Consortium: Yan-Shen Shan. Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium. JCO Precis Oncol. 2025 Oct:9:e2500696. (IF:5.8)
Yih-Jyh Lin, Da-Liang Ou, Yung-Yeh Su, Chia-Lang Hsu, Chin-Fu Hsiao, Bor-Sheng Ko, San-Chi Chen, Hung-Wei Wang, Jing-Houng Wang, Yao-Ming Wu, Yung-Ming Jeng, Wei-Chen Lee, Shu-Cheng Chou, Teng-Wei Chen, Chang-Fang Chiu, Jr-Shiuan Lin, Ching-Hung Hsieh, Chi-Chun Lee, Yan-Shen Shan, Ann-Lii Cheng*, Li-Tzong Chen*, Chiun Hsu*. Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: Long-term efficacy and biomarker exploration. J Hepatol. 2025 Sep 17:S0168-8278(25)02471-7. (IF:33.0)
Hui-Jen Tsai, Ming-Huang Chen, Hsiu-Po Wang, Chin-Fu Hsiao, Yen-Yang Chen, Jen-Shi Chen, Mei-Due Yang, Chin-Yuan Tzen, Yan-Shen Shan, Li-Yaun Bai, De-Chuan Chan, Pei-Yi Chu, Ching-Liang Ho, Youngsen Yang, Johnson Lin, Hsuan-Yu Lin, Cheng-Shyong Chang, Chuan-Cheng Wang, Tsann-Long Hwang, Li-Tzong Chen. Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study-TCOG T1214 study. Cancer. 2025 Sep 1;131(17):e70019. (IF:5.1)
Yang-Chen Shen, Po I Wu, Cheng-Feng Lin, Chia-Jui Yen, Yan-Shen Shan, Po See Chen. Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients. Kaohsiung J Med Sci. 2025 Aug 24:e70094. (IF:3.1)
Tanvi Gupta, Shang-Rung Wu, Li-Chan Chang, Forn-Chia Lin, Yan-Shen Shan, Chen-Sheng Yeh, Wen-Pin Su. Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer. J Nanobiotechnology. 2025 Aug 12;23(1):562. (IF:12.6)
Tzu-Lei Kuo, Ya-Chin Hou, Yan-Shen Shan, Li-Tzong Chen, Wen-Chun Hung. Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition. Clin Transl Med. 2025 Jul;15(7): e70394. (IF:6.8)
Ting-Kai Liao, Ying Jui Chao, Wei-Hsun Lu, Ping-Jui Su, Chih-Jung Wang, Yan-Shen Shan*. Risk Factors and Vascular Features Associated With Local Recurrence in Pancreatic Cancer Post-Pancreaticoduodenectomy: A Ret-rospective Cohort Study. Cancer Rep (Hoboken). 2025 Jul;8(7): e70267. (IF:1.9)
Yu-Ying Chao, Ruei-Ci Lin, Ping-Jui Su, Chu-An Wang, Ting-Yuan Tu, Ya-Chin Hou, Yi-Tzui Tsai, I-Chen Peng, Shaw-Jenq Tsai, Yan-Shen Shan and Chia-Yih Wang*. Melanophilin-induced primary cilia promote pancreatic cancer metastasis. Cell Death Dis. 2025 Jan 16;16(1):22. (IF:9.6)
Wei-Hsun Lu, Ying-Jui Chao, Ting-Kai Liao, Ping-Jui Su, Chih-Jung Wang, Yan-Shen Shan*. Effect of internal pancreatic duct stent on reducing long-term pancreaticojejunostomy stenosis following pancreaticoduodenectomy. Langenbecks Arch Surg.2025 Jan 27;410(1):51. (IF:1.8)
You-Ru Lin, Po-Chuan Chen, Wei-Ting Li, Min-Hsin Huang, Shu-Fen Huang, Chih-Jung Wang *, Yu-Wen Chien, Ai-Wen Kao, Yan-Shen Shan. The relationship between caloric intake and clinical outcomes in critically ill patients: A retrospective study. Clin Nutr ESPEN. 2025 Feb: 65:9-15. (IF:2.6)
Szu-Ying Chen, Yi-Hsien Fang, Chen-Yu Huang, Jou-Hsien Wu, Yan-Shen Shan , Yen-Wen Liu*, Po-Hsien Huang*.Transcriptome-wide RNA 5-methylcytosine profiles of human iPSCs and iPSC-derived cardiomyocytes. Sci Data. 2024 Dec 18;11(1):1378. (IF:6.9)
Hong Li, Chi-Ling Chiang, Kwang Joo Kwak, Xinyu Wang, Sital Doddi,Lakshmi V. Ramanathan, Sun M. Cho, Ya-Chin Hou, Tai-Shan Cheng, Xiaokui Mo,Yueh-Shih Chang, Hui-Lan Chang, Weiming Cheng, Wei-Ni Tsai, Luong T. H. Nguyen,Junjie Pan, Yifan Ma, Xilal Y. Rima, Jingjing Zhang, Eduardo Reategui, Yeh-Shiu Chu,Peter Mu-Hsin Chang, Pei-Hung Chang, Chi-Ying F. Huang*, Cheng-Hsu Wang*, Yan-Shen Shan*, Chung-Pin Li*, Martin Fleisher*, and L. James Lee*. Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis. Adv Sci (Weinh).2024 Mar;11(11). (IF:14.1)
Siao Muk Cheng, Yung‑Yeh Su, Nai‑Jung Chiang, Chih‑Jung Wang, Ying‑Jui Chao, Chien‑Jui Huang, Hui‑Jen Tsai, Shang‑Hung Chen, Chi‑Yen Chang, Chia‑Rung Tsai, Yi‑Jie Li, Chia‑Jui Yen, Shih‑Chang Chuang, Jeffrey Shu‑Ming Chang, Yan-Shen Shan*, Daw‑Yang Hwang* and Li‑Tzong Chen*. Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan. J Biomed Sci. 2024 Feb 13;31(1):21. (IF:12.1)
Pei-Chia Su, Ching-Yu Chen, Min-Hua Yu, I.-Ying Kuo, Pei-Shan Yang, Ching-Hsuan Hsu, Ya-Chin Hou, Hsin-Ta Hsieh, Chih-Peng Chang, Yan-Shen Shan*, Yi-Ching Wang*. Fully human chitinase-3 like-1 monoclonal antibody inhibits tumor growth, fibrosis, angiogenesis, and immune cell remodeling in lung, pancreatic, and colorectal cancers. Biomed harmacother. 2024 Jul: 176:116825. (IF:7.5)
Chang-Jung Chen, Hao-Chen Wang, Ya-Chin Hou, Yi-Ying Wu, Chi-Chang Shieh* and Yan-Shen Shan*. Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment. Mol Cancer Ther. 2024 Oct 1;23(10):1431-1445. (IF:5.5)
Chin-Wang Chen, Hao-Chen Wang, I-Min Tsai, I-Shu Chen, Chang-Jung Chen, Ya-Chin Hou , Yan‐Shen Shan*. CD204-positive M2-like tumor-associated macrophages increase migration of gastric cancer cells by upregulating miR-210 to reduce NTN4 expression. Cancer Immunol Immunother .2024 Jan 4;73(1):1. (IF:5.1)
Jui-Lin Chang, Chien-Jui Huang, Yi-Cheng Tsai, Nai-Jung Chiang, Yu-Shan Huang, Shang-Cheng Hung*, Yan‐Shen Shan* and Gwo-Bin Lee*. An integrated microfluidic system for automatic detection of cholangiocarcinoma cells from bile. Lab Chip. 2024 Jan 17;24(2):375-382 (IF:5.4)
Po See Chen*, Yang-Chen Shen, Cheng-Feng Lin, Ping-Yen Liu, Peng-Chan Lin, Pei-Fang Su, Chia-Jui Yen, Yan-Shen Shan. Prognostic Impacts of Depression and Inflammatory Factors in Pancreatic Cancer Patients. Biopsychosoc Sci Med.2025 Feb-Mar;87(2):146-152. (IF:2.4)
Leia R Jones , Maurice J W Zwart , Nine de Graaf , Kongyuan Wei, Liu Qu , Jin Jiabin, Fu Ningzhen, Shin-E Wang, Hongbeom Kim, Emanuele F Kauffmann, Roeland F de Wilde, I Quintus Molenaar , Ying Jui Chao , Luca Moraldi , Olivier Saint-Marc, Felix Nickel, Cheng-Ming Peng , Chang Moo Kang, Marcel Machado , Misha D P Luyer, Daan J Lips, Bert A Bonsing , Thilo Hackert, Yan-Shen Shan, Bas Groot Koerkamp, Yi-Ming Shyr , Baiyong Shen, Ugo Boggi , Rong Liu, Jin-Young Jang, Marc G Besselink, Mohammad Abu Hilal ; International Consortium on Minimally Invasive Pancreatic Surgery (I-MIPS). Learning curve stratified outcomes after robotic pancreatoduodenectomy: International multicenter experience. Surgery. 2024 Dec;176(6):1721-1729. (IF:2.7)
Hui-Jen Tsai, Shih-Hung Yang, Chin-Fu Hsiao, Hsiang-Fong Kao, Yung-Yeh Su, Yan-Shen Shan, Chia-Jui Yen, Jeng-Shiun Du, Chiun Hsu, I-Chen Wu, Li-Tzong Chen*. A phase 1 study of biweekly nab-paclitaxel/ oxaliplatin/S-1/LV for advanced upper gastrointestinal cancers: TCOG T1216 study. Oncologist.2024 Oct 3;29(10): e1396-e1405. (IF:4.2)
Shih-Hung Yang, Sung-Hsin Kuo, Jen-Chieh Lee, Bang-Bin Chen, Yan-Shen Shan, Yu-Wen Tien, Sz-Chi Chiu, Ann-Lii Cheng, Kun-Huei Yeh*. Adding-on nivolumab to chemotherapy-stabilized patients is associated with improved survival in advanced pancreatic ductal adenocarcinoma. Cancer Immunol Immunother. 2024 Sep 9;73(11):227. (IF:5.1)
Ping-Jui Su, Yen-Ta Huang, Ting-Kai Liao, Wei-Hsun Lu, Chih-Jung Wang, Ying-Jui Chao*, Yan-Shen Shan. Comparing survival after proximal gastrectomy vs. total gastrectomy in advanced gastric cancer: A systematic review and meta-analysis. Oncol Lett.2024 Jul 5;28(3):427. (IF:2.2)
Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai, Chuan-Cheng Wang, Ming-Tsan Lin, Chun-Fu Ting, De-Chuan Chan, Te-Hung Chen, Chueh-Chuan Yen, Yen-Yang Chen, Hsuan-Yu Lin, Ta-Sen Yeh, Ching-Liang Ho, Tze-Yu Shieh, Li-Yaun Bai, Jun-Te Hsu, I-Shu Chen, Li-Tzong Chen*, Chun-Nan Yeh* and Taiwan Cooperative Oncology Group (TCOG) GIST Study Group. Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study. BMC Cancer. 2024 Jul 11;24(1):828. (IF:3.4)
Cheng-Yu Tang, Shih-Hung Yang, Chung-Pin Li, Yung-Yeh Su, Sz-Chi Chiu, Li-Yuan Bai, Yan-Shen Shan, Li-Tzong Chen, Shih-Chang Chuang, De-Chuan Chan, Chia-Jui Yen, Cheng-Ming Peng, Tai-Jan Chiu, Yen-Yang Chen, Jen-Shi Chen, Nai-Jung Chiang*, Wen-Chi Chou*. Impact of previous S-1 treatment on efficacy of liposomal irinotecan plus 5-fluorouracil and leucovorin in patients with metastatic pancreatic cancer. Pancreatology.2024 Jun;24(4):600-607. (IF:2.7)
Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael W. Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang*, and Po-Hsien Huang*. Stromal Rigidity Stress Accelerates Pancreatic Intraepithelial Neoplasia Progression and Chromosomal Instability via Nuclear Protein Tyrosine Kinase 2 Localization. Am J Pathol. 2024 Jul;194(7):1346-1373. (IF:3.6)
Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sinyu Chen, Ming-Hsien Chan, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi zhang, Tai-Shan Cheng, Wen Jiang, Betty Kim, Eduardo Reátegui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F. Huang*, Yan‐Shen Shan*, Andrew Lee*. Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer. Nat Commun.2023 Oct (2023) 14(1):6692. (IF:15.7)
Yung-Yeh Su, Ying-Jui Chao, Chih-Jung Wang, Ting-Kai Liao, Ping-Jui Su, Chien-Jui Huang, Nai-Jung Chiang, Yu-Ting Yu, Hong-Ming Tsai, Li-Tzong Chen, Yan-Shen Shan*. The experience of neoadjuvant chemotherapy versus upfront surgery in resectable pancreatic cancer. a cross sectional study. Int J Surg. 2023 Sep 1;109(9):2614-2623. (IF:10.1)
Yu-Chun Lin, Ya-Chin Hou, Hao-Chen Wang and Yan-Shen Shan*. New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets. Theranostics. 2023 Jan; 13(12): 3925-3942. (IF:13.3)
Yung-Yeh Su, Nai-Jung Chiang, Yi-Hsin Yang, Chia-Jui Yen, Li-Yuan Bai,Chang-Fang Chiu, Shih-Chang Chuang, Shih-Hung Yang, Wen-Chi Chou, Jen-Shi Chen,Tai-Jan Chiu, Yen-Yang Chen, De-Chuan Chan, Cheng-Ming Peng, Sz-Chi Chiu,Chung-Pin Li, Yan-Shen Shan* and Li-Tzong Chen. Real-World Data Validation of NAPOLI-1 Nomogram for the Prediction of Overall Survival in Metastatic Pancreatic Cancer. Cancers 2023 Feb 5;15(4):1008. (IF:4.4)
Chih-Chieh Yen, Yi-Hsin Yang, Hsiu-Ying Ku, Huang-Ming Hu, Su-Shun Lo, Hung-Chi Chang, Yee Chao, Jen-Shi Chen, Hsiu-Po Wang, Tsang-En Wang, Li-Yuan Bai , Ming-Shiang Wu , Chia-Jui Yen, Li-Tzong Chen, Yan-Shen Shan*. The impact of preoperative waiting time in Stage II–III gastric or gastroesophageal junction cancer: A population-based cohort study. Cancer Med. 2023 Aug;12(16):16906-16917. (IF:3.1)
Chih-Jung Wang, Ying Jui Chao, Yi-Sheng Liu, Fan-Ting Liao, Shen-Shin Chang, Ting-Kai Liao, Wei-Hsun Lu, Ping-Jui Su, Yan-Shen Shan*. Prediction of surgical outcomes in severe encapsulating peritoneal sclerosis using a computed tomography scoring system. J Formos Med Assoc. 2024 Jan;123(1):98-105. (IF:2.5)
Daisuke Hashimoto, Sohei Satoi*, Tsutomu Fujii, Masayuki Sho, Jin He, Thilo Hackert, Marco Del Chiaro, Jin-Young Jang, Aiste Gulla, Yoo-Seok Yoon, Yan-Shen Shan, Wenhui Lou, Roberto Valente, Junji Furuse, Atsushi Oba, Minako Nagai, Taichi Terai, Haruyoshi Tanaka, Ayano Sakai, Tomohisa Yamamoto, So Yamaki, Ippei Matsumoto, Yoshiaki Murakami, Kyoichi Takaori, Yoshifumi Takeyama. Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto. Pancreatology.2023 Sep;23(6):682-688. (IF:2.7)
Yi-Hsien Fang, Saprina P. H. Wang, I-Chuang Liao, Kuen-Jer Tsai, Po-Hsien Huang, Pei-Jung Yang, Chia-Jui Yen, Ping-Yen Liu, Yan-Shen Shan, Yen-Wen Liu*.HLA-Ehigh /HLA-Ghigh /HLA-IIlow Human iPSC-Derived Cardiomyocytes Exhibit Low Immunogenicityfor Heart Regeneration. Adv Healthc Mater.2023 Nov;12(29). (IF:9.6)
Yu-Hsuan Hung, Ya-Chin Hou, Shih-Han Hsu, Li-Yun Wang, Ya-Li Tsai, Yan-Shen Shan, Yung-Yeh Su, Wen-Chun Hung*, Li-Tzong Chen*. Pancreatic cancer cell-derived semaphorin 3A promotes neuron recruitment to accelerate tumor growth and dissemination. Am J Cancer Res. 2023;13(8):3417-3432. (IF: 2.9)
Hung-Bin Wu, Chih-Hung Wang, Yi-Da Chung, Yan-Shen Shan, Ying-Jun Lin, HueyPin Tsai*, Gwo-Bin Lee*. Highly -specific aptamer targeting SARS-CoV-2 S1 protein screened on an automatic integrated microfluidic system for COVID-19 diagnosis. Anal Chim Acta. 2023 Sep 15:1274:341531. (IF:6.0)
Yen-Feng Chiu, Tsang-Wu Liu, Yan-Shen Shan, Jen-Shi Chen, Chung-Pin Li, Ching-Liang Ho, Ruey-Kuen Hsieh, Tsann-Long Hwang, Li-Tzong Chen, and Hui-Ju Ch’ang*, Taiwan Cooperative Oncology Group pancreatic cancer study group. Carbohydrate Antigen 19-9 Response to Initial Adjuvant Chemotherapy Predicts Survival and Failure Pattern of Resected Pancreatic Adenocarcinoma but Not Which Patients Are Suited for Additional Adjuvant Chemoradiation Therapy: From a Prospective Randomized Study. Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):74-86. (IF:6.5)
Cheng-Yu Tang, Shih-Hung Yang, Chung-Pin Li, Yung-Yeh Su, Sz-Chi Chiu, Li-Yuan Bai, Yan-Shen Shan , Li-Tzong Chen , Shih-Chang Chuang, De-Chuan Chan, Chia-Jui Yen , Cheng-Ming Peng, Tai-Jan Chiu, Yen-Yang Chen, Jen-Shi Chen, Nai-Jung Chiang**, Wen-Chi Chou q*.Impact of previous S-1 treatment on efficacy of liposomal irinotecan plus 5-fluorouracil and leucovorin in patients with metastatic pancreatic cancer. Pancreatology. 2024 Mar 25: S1424-3903(24)00076-0. (IF:2.7)
Tzu-Hui Wei , Ping-Jui Su, Wei-Hsun Lu , Ting-Kai Liao, Chih-Jung Wang , Chao-Han Lai , Pin-Hsuan Chiu , Pei-Fang Su , Ying-Jui Chao, Yan-Shen Shan . Minimally invasive approaches increase postoperative complications in obese patients undergoing pancreaticoduodenectomy during the initial development period: a propensity score matching study. Surg Endosc.2023 Apr;37(4):2770-2780. (IF:2.7)
Huey-Pin Tsai, Che-Wei Lin, Ying-Jun Lin, Chun-Sheng Yeh, Yan-Shen Shan. Novel Software for High-level Virological Testing: Self-Designed Immersive Virtual Reality Training Approach. J Med Internet Res. 2023 Jun 21;25: e44538. (IF:6.0)
Che-Yuan Hu, Hung-Tsung Wu, Yan-Shen Shan, Chung-Teng Wang, Gia-Shing Shieh,Chao-Liang Wu and Horng-Yih Ou. Evodiamine Exhibits Anti-Bladder Cancer Activity by Suppression of Glutathione Peroxidase 4 and Induction of Ferroptosis. Int. J. Mol. Sci. 2023, Mar 23;24(7):6021. (IF:4.9)
Wen‑Ruei Tang, Chun‑Hsien Wu, Tsung‑Han Yang, Yi‑Ting Yen, Kuo‑Shu Hung,Chih‑Jung Wang & Yan-Shen Shan. Impact of trauma teams on high grade liver injury care:a two‑decade propensity score approach study in Taiwan. Sci Rep. 2023 Apr 3;13(1):5429. (IF:3.9)
Yen-Feng Chiu,Tsang-Wu Liu, Yan-Shen Shan,Jen-Shi Chen,Chung-Pin Li, Ching-Liang Ho, Ruey-Kuen Hsieh, Tsann-Long Hwang, Li-Tzong Chen, andHui-Ju Ch’ang, on behalf of the Taiwan Cooperative Oncology Group pancreatic cancer study group. Carbohydrate Antigen19-9 Responseto Initial Adjuvant Chemotherapy Predicts Survival and Failure Pattern of Resected Pancreatic Adenocarcinoma but Not Which Patients Are Suited for Additional Adjuvant Chemoradiation Therapy: Froma Prospective Randomized Study. Int J Radiation Oncol Biol Phys. 2023 Apr 11; S0360-3016(23)00290-0. (IF:6.5)
Ying‑Jui Chao, Wei‑Hsun Lu, Ting‑Kai Liao, Ping‑Jui Su, Chih‑Jung Wang,Chao‑Han Lai, Jo‑Ying Hung, Pei‑Fang Su & Yan-Shen Shan. Feasibility of simultaneous development of laparoscopic and robotic pancreaticoduodenectomy. Sci Rep. 2023 Apr 16;13(1):6190. (IF: 3.9)
Shan-Ying Wu , Hung-Tsung Wu, Yi-Ching Wang, Chih-Jen Chang , Yan-Shen Shan, Shang-Rung Wu, Yen-Chi Chiu, Chia-Lang Hsu, Hsueh-Fen Juan , Kai-Ying Lan , Chi-Wen Chu, Ying-Ray Lee, Sheng-Hui Lan, Hsiao-Sheng Liu. Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2023 Apr;19(4):1239-1257. (IF:14.3)
Niccolo Napoli, Concetta Cacace, Emanuele F. Kauffmann, Leia Jones, Michael Ginesini, Cesare Gianfaldoni, Alice Salamone, Fabio Asta, Allegra Ripolli, Armando Di Dato, Olivier R. Busch, Marie L. Cappelle, Ying Jui Chao, Roeland F. de Wilde, Thilo Hackert, Jin-Young Jang, Bas Groot Koerkamp, Wooil Kwon, Daan Lips, Misha D.P. Luyer, Felix Nickel, Olivier Saint-Marc, Yan-Shen Shan, Baiyong Shen, Fabio Vistoli, Marc G. Besselink, Mohammad Abu Hilal, Ugo Boggi* , for the International Consortium on Minimally Invasive Pancreatic Surgery (I-MIPS). The PD-ROBOSCORE: A difficulty score for robotic pancreatoduodenectomy. Surgery 2023 Jun;173(6):1438-1446. (IF:3.2)
Margaret A. Tempero, Uwe Pelzer, Eileen M. O’Reilly, Jordan Winter, Do-Youn Oh,Chung-Pin Li, Giampaolo Tortora, Heung-Moon Chang, Charles D. Lopez, Tanios Bekaii-Saab, Andrew H. Ko, Armando Santoro, Joon Oh Park, Marcus S. Noel, Giovanni Luca Frassineti, Yan-Shen Shan, Andrew Dean, Hanno Riess, Eric Van Cutsem, Jordan Berlin, Philip Philip, Malcolm Moore, David Goldstein, Josep Tabernero,Mingyu Li, Stefano Ferrara, Yvan Le Bruchec, George Zhang, Brian Lu, Andrew V. Biankin, and Michele Reni, on behalf of the APACT Investigators. Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial. Journal of Clinical Oncology. 2023 Apr 10;41(11):2007-2019. (IF:41.9)
Hao‑Chen Wang, Lin‑Ya Haung, Chih‑Jung Wang, Ying‑Jui Chao, Ya‑Chin Hou, Chia‑Jui Yen and Yan-Shen Shan*. Tumor‑associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling. J Biomed Sci. 2022 Nov 21;29(1):99. (IF:12.1)
Tsung-Han Lu, Nai-Jung Chiang, Yi-Cheng Tsai, Priya Gopinathan, Chien-Jui Huang, Jui-Lin Chang, Hsiu-Chi Tu, Yan-Shen Shan*, Shang-Cheng Hung and Gwo-Bin Lee. An Integrated Microfluidic System for Cholangiocarcinoma Diagnosis from Bile by Using Specific Affinity Probes. Sens Actuator B Chem. 373(2022) 132724. (IF: 7.7)
Nai-Jung Chiang, Ya-Chin Hou, Kien Thiam Tan, Hung-Wen Tsai, Yih-Jyh Lin, Yi-Chen Yeh, Li-Tzong Chen, Ya-Fu Hou, Ming-Huang Chen*, Yan-Shen Shan*. The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma. Hepatol Int. 2022 Oct;16(5):1137-1149. (IF:6.1)
Ya-Chin Hou, Chien-Yu Chen, Chien-Jui Huang, Chih-Jung Wang, Ying-Jui Chao, Nai-Jung Chiang,Hao-Chen Wang, Hui-Ling Tung, Hsiao-Chun Liu and Yan-Shen Shan*. The Differential Clinical Impacts of Cachexia and Sarcopenia on the Prognosis of Advanced Pancreatic Cancer. Cancers (Basel) 2022 Jun 26;14(13):3137. (IF: 4.4)
Ying-Chun Yu, Azaj Ahmed, Hsueh-Chou Lai, Wei-Chung Cheng, Juan-Chern Yang, Wei-Chun Chang, Lu-Min Chen, Yan-Shen Shan* and Wen-Lung Ma. Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma. Front Oncol. 2022 Nov 17; 12:1057930. (IF:3.3)
Chien-Jui Huang, Wen-Yen Huang, Chien-Yu Chen, Ying-Jui Chao, Nai-Jung Chiang, Yan-Shen Shan*. Cancer-cell-derived cell-free DNA can predict distant metastasis earlier in pancreatic cancer: a prospective cohort study. Ther Adv Med Oncol. 2022; 14:1-13. (IF:4.2)
Yung-Yeh Su, Yu-Lin Ting, Chih-Jung Wang, Ying-Jui Chao, Ting-Kai Liao, Ping-Jui Su, Nai-Jung Chiang, I-Chuang Liao, Yu-Ting Yu, Yi-Sheng Liu, Hong-Ming Tsai, Yi-Jie Li, Chien-Jui Huang, I-Ting Liu, Hui-Jen Tsai, Chia-Jui Yen, Yan-Shen Shan*, Li-Tzong Chen. Improved survival with induction chemotherapy and conversion surgery in locally advanced unresectable pancreatic cancer: a single institution experience. Am J Cancer Res. 2022;12(5) :2189-2202 (IF:2.9)
Yung-Yeh Su, Nai-Jung Chiang, Chung-Pin Li, Chia-Jui Yen, Shih-Hung Yang, Wen-Chi Chou, Jen-Shi Chen, Tai-Jan Chiu, Yen-Yang Chen, Shih-Chang Chuang, Li-Yuan Bai, Chang-Fang Chiu, Cheng-Ming Peng, De-Chuan Chan, Sz-Chi Chiu, Yi-Hsin Yang, Yan-Shen Shan*, Li‐Tzong Chen. Dosing pattern and early cumulative dose of liposomal irinotecan in metastatic pancreatic cancer: a real-world multicenter study. Front Oncol. 2022 Jun 22; 12:800842. (IF:3.3)
Hsin-Hsien Yu , Hao-Chen Wang, Mao-Chih Hsieh, Ming-Che Lee, Bor-Chyuan Su, and Yan-Shen Shan*. Exendin-4 Attenuates Hepatic Steatosis by Promoting the Autophagy-Lysosomal Pathway. Biomed Res Int. 2022 Jul 15; 2022:4246086. (IF: 2.3)
Nai-Jung Chiang, Kien Thiam Tan, Li-Yuan Bai, Chin-Fu Hsiao, Chung-Yu Huang, Yi-Ping Hung, Chien-Jui Huang, San-Chi Chen , Yan-Shen Shan , Yee Chao, Yi-Hsiang Huang , I-Cheng Lee, Pei-Chang Lee, Yung-Yeh Su , Shu-Jen Chen, Chun-Nan Yeh, Li-Tzong Chen , Ming-Huang Chen. Impaired Chromatin Remodeling Predicts Survival to Modified Gemcitabine and S-1 plus Nivolumab in Advanced Biliary Tract Cancer: A Phase II T1219 Study. Clin Cancer Res. 2022 Oct 3;28(19):4248-4257. (IF:10.2)
Li-Yuan Bai , Chung-Pin Li , Yan-Shen Shan, Shih-Chang Chuang, Jen-Shi Chen , Nai-Jung Chiang, Yen-Yang Chen, Hsiao-Hui Tsou, Mei-Hsing Chuang, Chang-Fang Chiu , Tsang-Wu Liu , Li-Tzong Chen. A prospective phase II study of biweekly S-1, leucovorin, and gemcitabine in elderly patients with locally advanced or metastatic pancreatic adenocarcinoma – The Taiwan Cooperative Oncology Group T1217 study. Eur J Cancer. 2022 Sep; 173:123-132. (IF:7.1)
Ji Min Park, Jei-Ming Peng, Yu-Shiuan Shen, Chia-Ying Lin, Tung-Wei Hsu, Yen-Hao Su , Hsin-An Chen, Charupong Saengboonmee, Jung-Su Chang, Ching-Feng Chiu, Yan-Shen Shan. Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer. Mol Metab. 2022 Aug 19; 65:101576. (IF:6.6)
Yu-Shiuan Tsai, Chih-Hung Wang, Huey-Pin Tsai, Yan-Shen Shan, Gwo-Bin Lee*. Electromagnetically-driven Integrated Microfluidic Platform Using Reverse Transcription Loop-Mediated Isothermal Amplification for Detection of Severe Acute Respiratory Syndrome Coronavirus 2. Analytica Chimica Acta. 2022 Aug 1; 1219: 340036. (IF:6.0)
Wen-Pin Su, Li-Chan Chang, Wei-How Song, Li-Xing Yang, Liu-Chun Wang, Zi-Chun Chia, Yu-Cheng Chin, Yan-Shen Shan, Chih-Chia Huang, Chen-Sheng Yeh. Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer. ACS Appl Mater Interfaces. 2022 Jun 1;14(21):24144-24159. (IF:8.2)
Szu-Ying Chen, Kuan-Lin Chen, Li-Yun Ding, Chien-Hung Yu, Hsin-Yi Wu, Ya-Yi Chou, Chia-Jung Chang, Chih-Han Chang, Ya-Na Wu, Shang-Rung Wu, Ya-Chin Hou, Chung-Ta Lee, Peng-Chieh Chen, Yan-Shen Shan*, Po-Hsien Huang*. RNA bisulfite sequencing reveals NSUN2-mediated suppression of epithelial differentiation in pancreatic cancer. Oncogene. 2022 May;41(22):3162-3176. (IF:7.3)
You-Ru Jhou, Chih-Hung Wang, Huey-Pin Tsai, Yan-Shen Shan, Gwo-Bin Lee. An integrated microfluidic platform featuring real-time reverse transcription loop-mediated isothermal amplification for detection of COVID-19. Sens Actuator B Chem. 2022 May 1; 358:131447. (IF: 7.7)
Shih-Hung Yang, Nai-Jung Chiang, Sz-Chi Chiu, Wen-Chi Chou, Li-Yuan Bai, Chung-Pin Li, Yung-Yeh Su, Tai-Jan Chiu, Shih-Chang Chuang, Cheng-Ming Peng, De-Chuan Chan, Jen-Shi Chen, Chia-Jui Yen, Yen-Yang Chen, Chang-Fang Chiu, Li-Tzong Chen, Yan-Shen Shan*. The impact of spleen volume on the survival of metastatic pancreatic adenocarcinoma patients receiving nanoliposomal irinotecan. Am J Cancer Res. 2022 Apr 15;12(4):1884-1898. (IF:2.9)
Yung-Yeh Su, Yen-Feng Chiu, Chung-Pin Li, Shih-Hung Yang, Johnson Lin, Shyh-Jer Lin, Ping-Ying Chang, Nai-Jung Chiang, Yan-Shen Shan*, Hui-Ju Ch’ang*, Li-Tzong Chen*. A phase II randomised trial of induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced pancreatic cancer: The Taiwan Cooperative Oncology Group T2212 study. Br J Cancer. 2022 Apr;126(7):1018-1026. (IF:6.8)
Shih-Huang Tai, Sheng-Yang Huang, Liang-Chun Chao, Yu-Wen Lin, Chien-Chih Huang, Tian-Shung Wu, Yan-Shen Shan, Ai-Hua Lee, E-Jian Lee. Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period. Neurol Res. 2022 Mar 29;1-9. (IF:3.2)
Yu-Hsuan Hung, Shih-Han Hsu, Ya-Chin Hou, Pei-Yi Chu, Yung-Yeh Su, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen. Semaphorin 6C Suppresses Proliferation of Pancreatic Cancer Cells via Inhibition of the AKT/GSK3/β-Catenin/Cyclin D1 Pathway. Int J Mol Sci. 2022 Feb 26;23(5):2608. (IF:4.9)
Tai-Jan Chiu, Shih-Hung Yang, Sz-Chi Chiu, Shun-Wen Hsueh, Nai-Jung Chiang, Chung-Pin Li, Li-Yuan Bai, Fu-Ming Cheng, Shih-Chang Chuang, Yan-Shen Shan, De-Chuan Chan, Li-Tzong Chen, Chia-Jui Yen, Cheng-Ming Peng, Yung-Yeh Su, Yen-Yang Chen, Jen-Shi Chen, Wen-Chi Chou. Effect of previous conventional irinotecan treatment in patients with pancreatic cancer being treated with liposomal irinotecan plus 5-fluorouracil and leucovorin. J Hepatobiliary Pancreat Sci. 2022 Jun;29(6):670-681. (IF:2.8)
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan*, Yi-Ching Wang*. Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy. Theranostics. 2022 Jan 1;12(1):340-361. (IF:13.3)
Chih-Jung Wang, Tsung-Han Yang, Kuo-Shu Hung, Chun-Hsien Wu, Shu-Ting Yen, Yi-Ting Yen, Yan-Shen Shan. Regular feedback on inter-hospital transfer improved the clinical outcome and survival in patients with multiple trauma: a retrospective cohort study. BMC Emerg Med. 2021 Dec 3;21(1):150. (IF:2.6)
Tai-Jan Chiu, Yung-Yeh Su, Shih-Hung Yang, Chung-Pin Li, Li-Yuan Bai, Nai-Jung Chiang, Shih-Chang Chuang, Yan-Shen Shan, De-Chuan Chan, Li-Tzong Chen, Chia-Jui Yen, Cheng-Ming Peng, Yen-Yang Chen, Jen-Shi Chen, Wen-Chi Chou. Liposomal irinotecan pre-emptive dose reduction in patients with pancreatic ductal adenocarcinoma: 667 patients’ experience within a population-based study. Ther Adv Med Oncol. 2021 Nov 20; 13:17588359211058255. (IF:4.2)
Huang-Ming Hu, Hui-Jen Tsai, Hsiu-Ying Ku, Su-Shun Lo, Yan-Shen Shan, Hung-Chi Chang, Yee Chao, Jen-Shi Chen, Shu-Chen Chen, Chun-Ju Chiang, Anna Fen-Yau Li, Hsiu-Po Wang, Tsang-En Wang, Li-Yuan Bai, Ming-Shiang Wu, Li-Tzong Chen, Tsang-Wu Liu, Yi-Hsin Yang. Survival outcomes of management in metastatic gastric adenocarcinoma patients. Sci Rep. 2021 Nov 30;11(1):23142. (IF: 3.9)
Hui-Jen Tsai, Chin-Fu Hsiao, Jeffrey S Chang, Li-Tzong Chen, Ying-Jui Chao, Chia-Ju Yen, Yan-Shen Shan*. The Prognostic and Predictive Role of Chromogranin A in Gastroenteropancreatic Neuroendocrine Tumors – A Single-Center Experience. Front Oncol. 2021 Nov 12; 11:741096. (IF:3.3)
Priya Gopinathan, Tsung-Han Lu, Nai-Jung Chiang, Chien-Jui Huang, Hsui-Chi Tu, Shang-Cheng Hung*, Yan-Shen Shan*, Gwo-Bin Lee*. Exfoliated tumor cells in bile as a promising indicator of disease status in cholangiocarcinoma. Sens Actuator B Chem. 2021 Nov 1; 346:130526. (IF: 7.7)
Chia-Lung Yang, Ying-Jui Chao, Hao-Chen Wang, Ya-Chin Hou, Caleb Gonshen Chen, Chia-Ching Chang, Yan-Shen Shan*. Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs. Nanomed.-Nanotechnol Biol Med. 2021 Oct;37:102450. (IF:4.6)
Chih-Chieh Yen, Chia-Jui Yen, Yan-Shen Shan, Yih-Jyh Lin, I-Ting Liu, Hsuan-Yi Huang, Matthew M Yeh, Shih-Huang Chan, Hung-Wen Tsai. Comparing the clinicopathological characteristics of combined hepatocellular–cholangiocarcinoma with those of other primary liver cancers by use of the updated World Health Organization classification. Histopathology. 2021 Oct;79(4):556-572. (IF:4.1)
Hung-Hsiang Jen, Husam Kafeenah, Ting-Yao Chang, Yu-Min Lin, Yan-Shen Shan, Chih-Hsing Wu, Shu-Hui Chen. Quantification of the Endogenous Adduction Level on Hemoglobin and Correlation with Albumin Adduction via Proteomics: Multiple Exposure Markers of Catechol Estrogen. J Proteome Res. 2021 Sep 3;20(9):4248-4257. (IF:3.8)
Peng-Chan Lin, Yu-Min Yeh, Hui-Ping Hsu, Ren-Hao Chan, Bo-Wen Lin, Po-Chuan Chen, Chien-Chang Pan, Keng-Fu Hsu, Jenn-Ren Hsiao, Yan-Shen Shan, Meng-Ru Shen. Comprehensively Exploring the Mutational Landscape and Patterns of Genomic Evolution in Hypermutated Cancers. Cancers (Basel). 2021 Aug 26;13(17):4317. (IF: 4.4)
Yan-Shen Shan, Li-Tzong Chen, Chih-Hsing Wu, Yin-Fan Chang, Chih-Ting Lee, Nai-Jung Chiang, Ying-Jui Chao, Chia-Jui Yen, Hui-Jen Tsai, Hsin-En Huang, Chia-Rung Tsai, Ya-Ling Weng, Han-Chien Yang, Hui-Chin Liu, Jeffrey S Chang. No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol. Sci Rep. 2021 Jul 15;11(1):14567. (IF: 3.9)
Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen, Hsuan-Yi Huang, I-Ting Liu, Chia-Jui Yen. Surgery alone, adjuvant tegafur/gimeracil/octeracil (S-1), or platinum-based chemotherapies for resectable gastric cancer: real-world experience and a propensity score matching analysis. BMC Cancer. 2021 Jul 9;21(1):796. (IF:3.4)
Ying-Jui Chao, Ting-Kai Liao, Ping-Jui Su, Chih-Jung Wang, Yan-Shen Shan*. Impact of body mass index on the early experience of robotic pancreaticoduodenectomy. Updates Surg. 2021 Jun;73(3):929-937. (IF:2.2)
Chung-Chi Hsu, Wen-Ying Liao, Kwang-Yu Chang, Tze-Sian Chan, Po-Jui Huang, Chun-Ting Chiang, Yan-Shen Shan, Lin-Hsin Cheng, Tai-Yan Liao, Kelvin K Tsai. A multi-mode Wnt- and stemness-regulatory module dictated by FOXM1 and ASPM isoform I in gastric cancer. Gastric Cancer. 2021 May;24(3):624-639. (IF:5.1)
Divinah Manoharan, Li-Chan Chang, Liu-Chun Wang, Yan-Shen Shan, Forn-Chia Lin, Lai-Chin Wu, Hwo-Shuenn Sheu, Wen-Pin Su, Chen-Sheng Yeh. Synchronization of Nanoparticle Sensitization and Radiosensitizing Chemotherapy through Cell Cycle Arrest Achieving Ultralow X-ray Dose Delivery to Pancreatic Tumors. ACS Nano. 2021 May 25;15(5):9084-9100. (IF:16.0)
Shu-Ling Pen, Yan-Shen Shan, Chin-Fu Hsiao, Tsang-Wu Liu, Jen-Shi Chen, Ching-Liang Ho, Wen-Chi Chou, Ruey-Kuen Hsieh, Li-Tzong Chen, Hui-Ju Ch’ang. High expression of krüppel-like factor 10 or Smad4 predicts clinical benefit of adjuvant chemoradiotherapy in curatively resected pancreatic adenocarcinoma: From a randomized phase III trial. Radiother Oncol. 2021 May; 158:146-154. (IF:5.3)
Jeffrey S Chang, Li-Tzong Chen, Yan-Shen Shan, Pei-Yi Chu, Chia-Rong Tsai, Hui-Jen Tsai. An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan. Sci Rep. 2021 Apr 12;11(1):7881. (IF: 3.9)
Chih-Wei Chen, Cheng-Han Yang, Yuan-Ho Lin, Ya-Chin Hou, Tain-Junn Cheng, Sheng-Tsung Chang, Yu-Hua Huang, Shang-Ting Chung, Chung-Ching Chio, Yan-Shen Shan, Hung-Chi Cheng, Wen-Tsan Chang. The Fibronectin Expression Determines the Distinct Progressions of Malignant Gliomas via Transforming Growth Factor-Beta Pathway. Int J Mol Sci. 2021 Apr 6;22(7):3782. (IF:4.9)
Nai-Jung Chiang, Li-Tzong Chen, Yan-Shen Shan, Chun-Nan Yeh, Ming-Huang Chen. Development of Possible Next Line of Systemic Therapies for Gemcitabine-Resistant Biliary Tract Cancers: A Perspective from Clinical Trials. Biomolecules. 2021 Jan 13;11(1):97. (IF:4.8)
Chih-Yang Wang, Ying-Jui Chao, Yi-Ling Chen, Tzu-Wen Wang, Nam Nhut Phan, Hui-Ping Hsu, Yan-Shen Shan, Ming-Derg Lai. Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer. Int J Med Sci. 2021 Jan 1;18(1):256-269. (IF:3.2)
Tsung-Ming Chang, Pei-Yi Chu, Wen-Chun Hung, Yan-Shen Shan, Hui-You Lin, Kuo-Wei Huang, Jeffrey S Chang, Li-Tzong Chen, Hui-Jen Tsai. c-Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation. Cancer Sci. 2021 Jan;112(1):243-253. (IF:4.3)

探討血清澱粉樣蛋白A在胰臟癌早期診斷與預後預測中的應用潛力(1/3)(114-2622-B-006-012-)

以多面向實施策略開發針對胰臟癌腫瘤微環境的新穎靶向療法及強化其傳遞技術－推動新型精準基因藥物—應用細胞外囊泡傳遞治療性信使核糖核酸、小干擾核糖核酸及誘騙寡核?酸於胰臟癌治療(3/3)(114-2314-B-006-005-)

應用多組學引導的精準腫瘤學以發現和治療由組織缺氧-纖維化循環介導的胰臟腫瘤進展(114-2314-B-006-096-MY3)

超高齡社會之精準再生醫學啟航計畫－以疾病為導向開發具基因編輯細胞治療平台(4/4)() NSTC 114-2321-B-006-014

跨中心多體學與液體活檢導引之胰臟癌早期診斷與預後評估整合平台 (1/4)(MOHW115-TDU-B-221-114015)

衛福部-臨床試驗新型態卓越計畫

以多面向實施策略開發針對胰臟癌腫瘤微環境的新穎靶向療法及強化其傳遞技術－推動新型精準基因藥物—應用細胞外囊泡傳遞治療性信使核糖核酸、小干擾核糖核酸及誘騙寡核苷酸於胰臟癌治療(2/3)( NSTC113/08/01-114/07/31)

探討癌症惡病質之脂肪流失在胰腺癌發展中的角色(3/3)(MOST113/08/01-114/07/31)

超高齡社會之精準再生醫學啟航計畫－以疾病為導向開發具基因編輯細胞治療平台(3/3) (NSTC113/05/01 -114/04/30)

多面向評估早期診斷及個人化介入措施演算法應用於胰臟癌篩檢與治療之多中心研究(第3年) (MOHW113/01/01 -113/12/31)

113年臨床試驗新型態卓越計畫(MOHW113/01/01 -113/12/31)

以多面向實施策略開發針對胰臟癌腫瘤微環境的新穎靶向療法及強化其傳遞技術－推動新型精準基因藥物—應用細胞外囊泡傳遞治療性信使核糖核酸、小干擾核糖核酸及誘騙寡核苷酸於胰臟癌治療(1/3)( NSTC112/08/01-113/07/31)

探討癌症惡病質之脂肪流失在胰腺癌發展中的角色(2/3)( MOST112/08/01-113/07/31)

建立台灣上消化道癌症臨床資料資訊平台(NSTC112/07/01-113/06/30)

以疾病為導向開發具基因編輯細胞治療平台－以疾病為導向開發具基因編輯細胞治療平台(2/3)( NSTC112/05/01 -113/04/30)

多面向評估早期診斷及個人化介入措施演算法應用於胰臟癌篩檢與治療之多中心研究(第1年)( MOHW112/01/01 -112/12/31)

衛生福利部「推動臨床試驗發展計畫」(MOHW 112/01/01 -112/12/31)

探討癌症惡病質之脂肪流失在胰腺癌發展中的角色(1/3)( MOST111/08/01-112/07/31)

以多重研究法解開組織缺氧-纖維化循環在胰臟癌之病理機制及發展新穎治療策略－組織缺氧-纖維化循環在胰臟癌生成與進展、免疫抑制及抗藥性之角色：聚焦於癌細胞與癌症相關纖維母細胞交互作用(3/3)( NSTC 111/08/01-112/07/31)

建立台灣上消化道癌症臨床資料資訊平台(NSTC111/07/01-112/06/30)

以疾病為導向開發具基因編輯細胞治療平台－以疾病為導向開發具基因編輯細胞治療平台(1/3)( MOST111/05/01 -112/04/30)

多面向評估早期診斷及個人化介入措施演算法應用於胰臟癌篩檢與治療之多中心研究(第1年) (MOHW111/01/01 -111/12/31)

衛生福利部「推動臨床試驗發展計畫」(MOHW111/01/01 -111/12/31)

建立台灣上消化道癌症臨床資料資訊平台(MOST110/10/01-111/06/30)

以多重研究法解開組織缺氧-纖維化循環在胰臟癌之病理機制及發展新穎治療策略－組織缺氧-纖維化循環在胰臟癌生成與進展、免疫抑制及抗藥性之角色：聚焦於癌細胞與癌症相關纖維母細胞交互作用(2/3)( MOST110/08/01-111/07/31)

A20 在胃癌的鐘擺化療法中造成藥物阻抗所扮演角色之研究(第二與第三年計畫)(2/2)( MOST110/08/01-111/07/31)