蔡坤哲 – 國立成功大學-臨床醫學研究所

研究領域在基礎神經科學與臨床神經醫學，主要研究方向針對神經退化性疾病相關的失智症，包含阿茲海默氏症、額顳葉退化症、缺血性中風、出血性中風與頭部外傷造成認知功能喪失。實驗假設主要以分子生物學與細胞生物學之技術進行觀察與驗證，並搭配疾病動物模式及行為檢測等技術輔助，釐清其功能性表徵及生理機制，為相關學術領域提供具有創新性和重要性的研究知識，以期能深入探討失智症相關致病機轉及開發新治療策略，以達轉譯醫學之目的。

2011年有庠科技論文獎(生技醫藥類)

2011年成功大學醫學院新人最佳論文獎

2021年成杏優秀論文獎與成大醫院優秀論文獎勵

2022年成杏優秀論文獎與成大醫院優秀論文獎勵

2022年第十九屆國家新創獎-學研新創獎

2023年成杏優秀論文獎與成大醫院優秀論文獎勵

2023年成大醫學院最佳論文獎-基礎醫學組

2024年成杏優秀論文獎與成大醫院優秀論文獎勵

2025年成杏優秀論文獎與成大醫院優秀論文獎勵

2025年國科會未來科技獎

2025年第二十二屆國家新創獎-學研新創獎

2021.08~ 成功大學臨床醫學研究所專任特聘教授
2017.08~ 成功大學醫學院附設醫院臨床醫學研究中心副主任
2017.08~2021.07 成功大學臨床醫學研究所專任教授
2012.08~2017.07 成功大學臨床醫學研究所專任副教授
2010.02~2012.07 成功大學臨床醫學研究所專任助理教授
2002.04~2009.02 中央研究院分子生物研究所博士後研究

Kuo J.H., Chuang M.S., Jan H.C., Ho Y.H., Kao Y.L., Tsai K.J.*, Ou Y.C.* (2025). Predicting Initial Trial Without Catheter Failure After Prostate Deobstruction Surgery Using Preoperative Urodynamics. Int Neurourol J. 2025 Nov 4.
Ling T.C., Chang C.C., Wu J.L., Lin W.R., Sun C.Y., Huang C.H., Tsai K.J., Chang Y.T. (2025). Development of Machine-Learning-Based Models for Detection of Cognitive Impairment in Patients Receiving Maintenance Hemodialysis. Eur J Neurol. 2025 Jun;32(6):e70246.
Pang Y.L., Fang S.Y., Huang C.C., Lin M.W., Roan J.N., Tsai K.J., Lam C.F.* (2025). TRANSPLANTATION OF VIABLE ALLOGENEIC MITOCHONDRIA PROTECTS KIDNEY FUNCTION IN A MOUSE MODEL OF HEMORRHAGIC SHOCK AND RHABDOMYOLYSIS-INDUCED ACUTE RENAL INJURY. Shock. 2025 Jun 1;63(6):929-934.
Ho P.C., Hsieh T.C., Tsai K.J.* (2024). TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: From pathomechanisms to therapeutic strategies. Ageing Res Rev. 2024 Jul 27;100:102441.
Lee H.W., Chen S.J., Tsai K.J., Hsu K.S., Chen Y.F., Chang C.H., Lin H.H., Hsueh W.Y., Hsieh H.P., Lee Y.F., Chiang H.C., Chang J.Y.* (2024). Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function. J Biomed Sci. 2024 May 9;31(1):46.
Hung J.H., Tsai P.H., Aala W.J.F., Chen C.C., Chiou S.H., Wong T.W., Tsai K.J., Hsu S.M.*, Wu L.W.* (2024). TIMP3/Wnt axis regulates gliosis of Müller glia. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167087.
Fang Y.H., Wang S.P.H., Liao I.C., Tsai K.J., Huang P.H., Yang P.J., Yen C.J., Liu P.Y., Shan Y.S., Liu Y.W.* (2023). HLA-Ehigh /HLA-Ghigh /HLA-IIlow Human iPSC-Derived Cardiomyocytes Exhibit Low Immunogenicity for Heart Regeneration. Advanced Healthcare Materials. 2023 Nov;12(29):e2301186.
Chu Y.P., Ho P.C., Tsai K.J.* (2023). TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy. Autophagy. 19(8):2403-2405.
Abijo A., Lee C.Y., Huang C.Y., Ho P.C., Tsai K.J.* (2023). The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases. Biomedicines. 26;11(7):1828.
Hsu Y.T., Chen L.H., Liu Y.H., Chu S.K., Chen T.Y., Tsai K.J., Shen M.R.*, Liu W.* (2023). Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy. Small Methods. 2023 Jun;7(6):e2201300.
Chu Y.P., Jin L.W., Wang L.C., Ho P.C., Wei W.Y., Tsai K.J.* (2023). Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP. Brain. 2;146(5):2089-2106.
Ou Y.C., Huang C.C., Kao Y.L., Ho P.C., Tsai K.J.* (2023). Stem Cell Therapy in Spinal Cord Injury-Induced Neurogenic Lower Urinary Tract Dysfunction. Stem Cell Reviews and Reports. 19, 1691–1708.
Kao Y.L., Ou Y.C., Tsai K.J., Kuo H.C.* (2022). Predictive Factors for a Successful Treatment Outcome in Patients with Different Voiding Dysfunction Subtypes Who Received Urethral Sphincter Botulinum Injection. Toxins. 2022; 14(12):877.
Wang I.F., Ho P.C., Tsai K.J.* (2022). MicroRNAs in Learning and Memory and Their Impact on Alzheimer’s Disease. Biomedicines, 10(8):1856.
Jan M.W., Chiu C.Y., Chen J.J., Chang T.H., Tsai K.J.* (2022). Human Platelet Lysate Induces Antiviral Responses against Parechovirus A3. Viruses-Basel, 14(7):1499.
Wong C.E., Chu Y.P., Tsai K.J.* (2022). Structure-Based Analysis of Protein Cluster Size for Super-Resolution Microscopy in the Nervous System. Biomedicines, 27;10(2):295.
Jan M.W., Su H.L., Chang T.H., Tsai K.J.* (2021). Characterization of Pathogenesis and Inflammatory Responses to Experimental Parechovirus Encephalitis. Frontiers in Immunology, 5013.
Wang L.C.*, Wei W.Y., Ho P.C., Wu P.Y., Chu Y.P., Tsai K.J.* (2021). Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain. Frontiers in Aging Neuroscience, 13:741168.
Ling T.C., Chang C.C., Li C.Y., Sung J.M., Sun C.Y., Tsai K.J., Cheng Y.Y., Wu J.L., Kuo Y.T., Chang Y.T.* (2021). Development and validation of the dialysis dementia risk score: A retrospective, population-based, nested case-control study. European Journal of Neurology, 2021 Sep 24.
Sung P.S., Lee K.P., Lin P.Y., Su H.C., Yu R.L., Tsai K.J., Lin S.H., Chen C.H.* (2021). Factors Associated with Cognitive Outcomes After First-Ever Ischemic Stroke: The Impact of Small Vessel Disease Burden and Neurodegeneration. Journal of Alzheimer’s Disease, 83(2):569-579.
Sung P.S., Chen P.W., Yen C.J., Shen M.R., Chen C.H., Tsai K.J.*, Lin C.K.* (2021). Memantine Protects against Paclitaxel-Induced Cognitive Impairment through Modulation of Neurogenesis and Inflammation in Mice. Cancers (Basel), 19;13(16):4177.
Wang I.F., Wang Y.H., Yang Y.H., Huang G.J., Tsai K.J.*, Shen C.K.J.* (2021). Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability. Cell Reports, 36(5):109477.
Hung P.H., Yeh C.C., Hsiao C.Y., Muo C.H., Hung K.Y., Tsai K.J.* (2021). Erythropoietin Use and the Risk of Stroke in Patients on Hemodialysis: A Retrospective Cohort Study in Taiwan. Journal of the American Heart Association, e019529.
Ou Y.C., Huang K.H., Jan H.C., Kuo H.C., Kao Y.L., Tsai K.J.* (2021). Therapeutic Efficacy of Urethral Sphincteric Botulinum Toxin Injections for Female Sphincter Dysfunctions and a Search for Predictive Factors. Toxins (Basel), 2;13(6):398.
Wong C.E., Jin L.W., Chu Y.P., Wei W.Y., Ho P.C., Tsai K.J.* (2021) TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism. Theranostics, 11(1): 330-345.
Chuang H.C., Tsai K.L., Tsai K.J., Tu T.Y., Shyong Y.J., Jou I.M., Hsu C.C., Shih S.S., Liu Y.F., Lin C.L.* (2020). Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways. Aging-US, 2020 Nov 20;12.
Chen, P.C., Hsueh, Y.W., Lee, Y.H., Tsai, H.W., Tsai, K.J., Chiang, P.M.* (2020). FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK. Cellular and Molecular Life Sciences, 78, 2199;212.
Su I.J., Chang H.Y., Wang H.C., Tsai K.J.* (2020) A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer’s Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. International Journal of Molecular Sciences, 30;21(15):5459.
Wu C.C., Jin L.W., Wang I.F., Wei W.Y., Ho P.C., Liu Y.C., Tsai K.J.* (2020) HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies. EMBO Molecular Medicine, 12(6):e10622.
Kao Y.C., Ho P.C., Tu Y.K., Jou I.M., Tsai K.J.* (2020) Lipids and Alzheimer’s Disease. International Journal of Molecular Sciences, 21, 4, 1505.
Yoshihito H, Lin H.T., Lee C.C., Tsai K.J.* (2020) Effects of Neural stem cell transplantation in Alzheimer’s disease models. Journal of Biomedical Science, 27, 29.
Sung P.S., Lin P.Y., Liu C.H., Su H.C., Tsai K.J.* (2020) Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches. International Journal of Molecular Sciences, 21(3):701.
Lee T.L., Liu C.H., Chang Y.M., Lin T.Y., Chien C.Y., Chen C.H., Tsai K.J., Lin S.H., Sung P.S.* (2020) The Impact of Antiplatelet Use on the Risk of Intracerebral Hemorrhage in Patients with Alzheimer’s Disease. Journal of Alzheimer’s Disease, doi: 10.3233/JAD-190762.
Kao Y.C., Wei W.Y., Wang L.C.*, Tsai K.J.* (2019) High Fat Diet Suppresses Peroxisome Proliferator-activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International Journal of Molecular Sciences, 21(1):207.
Hung P.H., Yeh C.C., Sung F.C., Hsiao C.Y., Muo C.H., Hung K.Y., Tsai K.J.* (2019) Erythropoietin prevents dementia in hemodialysis patients. Aging-US, 11(17):6941-6950.
Liao H.W., Huang T.H., Chang Y.H., Liou H.H., Chou Y.H., Sue Y.M., Hung P.H., Chang Y.T., Ho P.C., Tsai K.J.* (2019) Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production. International Journal of Molecular Sciences, 20(8): 2044.
Pai M.C., Kuo Y.M., Wang I.F., Chiang P.M., Tsai K.J.* (2019) The role of methylated circulating nucleic acids as a potential biomarker in Alzheimer’s disease. Molecular Neurobiology, 56(4):2440-2449.
Wu C.C., Wang L.C., Su Y.T., Wei W.Y., Tsai K.J.* (2018) Synthetic α5β1 Integrin Ligand PHSRN is Proangiogenic and Neuroprotective in Cerebral Ischemic Stroke. Biomaterials, 185:142-154.
Kao Y.C., Wang I.F., Tsai K.J.* (2018). miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline. International Journal of Molecular Sciences, 19(8):2323.
Hung C.L., Yeh C.C., Sung P.S., Hung C.J., Muo C.H., Sung F.C., Jou I.M., Tsai K.J.* (2018) Is Partial or Total Thyroidectomy Associated with Risk of Long-Term Osteoporosis. World Journal of Surgery, doi: 10.1007/s00268-018-4573-2.
Wu C.C., Wang I.F., Chiang P.M., Wang L.C., Shen C.J., Tsai K.J.* (2017) G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis. Molecular Neurobiology, 54(8):6198-6212.
Wang L.C., Wu C.L., Cheng Y.Y., Tsai K.J.* (2017). Deletion of nuclear localizing signal attenuates pro-inflammatory activity of Prothymosin-alpha and enhances its neuroprotective effect on transient ischemic stroke. Molecular Neurobiology, 54(1):582-593.
Hung P.H., Yeh C.C., Hsiao C.Y., Sung P.S., Muo C.H., Sung F.C., Hung K.Y., Tsai K.J.* (2017) End stage renal disease is associated with development of dementia. Oncotarget, 8(64):107348-107355.
Sung P.S., Yeh C.C., Wang L.C., Hung P.H., Muo C.H., Sung F.C., Chen C.H., Tsai K.J.* (2017) Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder. Current Alzheimer Research, 14(3):309-316.
Lee Y.H., Hsueh Y.W., Peng Y.H., Chang K.C., Tsai K.J., Sun H.S., Su I.J., Chiang P.M.* (2017) Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium. BMC Biology, 15(1):22.
Wu P.T., Kuo L.C., Su F.C., Chen S.Y., Hsu T.I., Li C.Y., Tsai K.J.*, Jou I.M.* (2017). High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy. Scientific Reports, 2017 7:40840.
Tsai K.J., Sze C.I., Lin Y.C., Lin Y.J., Hsieh T.H., Lin C.H.* (2016, Oct). A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life. PLoS One, 11(10):e0165752.
Wu C.C., Lien C.C., Hou W.H., Chiang P.M., Tsai K.J.* (2016) Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease. Scientific Report, 6:27358.
Wang L.C., Wu C.L., Cheng Y.Y., Tsai K.J.* (2016) Deletion of nuclear localizing signal attenuates pro-inflammatory activity of Prothymosin-alpha and enhances its neuroprotective effect on transient ischemic stroke. Molecular Neurobiology, 2016 Jan.
Huang C.Y., Wang L.C., Wang H.K., Pan C.H., Cheng Y.Y., Shan Y.S., Chio C.C., Tsai K.J.* (2015) Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage. Molecular Neurobiology, 51(3):1038-1052.
Wu M.H., Huang C.C., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Lin M.T.* (2015) Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. Molecular Neurobiology, 2015 Sep 15.
Wu M.H., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Huang C.C., Lin M.T. (2015) Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis. Molecular Neurobiology, 2015 Jul 1.
Wang H.K., Lee Y.C., Huang C.Y., Liliang P.C., Lu K., Chen H.J., Li Y.C., Tsai K.J.* (2015) Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis. Neurosciences, 300, 94-103.
Liao H.W., Hung P.H., Hsiao C.Y., Liou H.H., Lin H.S., Huang T.H., Jou I.M., Tsai K.J.* (2015) Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy. PLoS One, 10(7):e0133278.
Wu Y.T., Yu I.S., Tsai K.J., Shih C.Y., Hwang S.M., Su I.J., Chiang P.M.* (2015) Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system. Scientific Report, 5:9718
Huang C.Y., Li Y.C., Wang H.K., Sung P.S., Wang L.C., Sun Y.T., Pan C.H., Tsai K.J.* (2015) Stroke suggests increased risk of dementia. Current Alzheimer Research, 12(3):287-295.
Wang I.F., Tsai K.J.*, Shen C.K.* (2015) Spermidine on neurodegenerative diseases. Cell Cycle, 14(5):697-698.
Fang Y.S., Tsai K.J., Chang Y.J., Kao P., Woods R., Kuo P.H., Wu C.C., Liao J.Y., Chou S.C., Lin V., Jin L.W., Yuan H., Cheng I., Tu P.H., Chen Y.R.* (2014) Full-Length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients. Nature Communications, 5:4284.
Huang L.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Prevalence, incidence, and comorbidity of clinically diagnosed obsessive-compulsive disorder in Taiwan: A national population-based study. Psychiatry Research, 2014 Aug 15. pii: S0165-1781.
Lu K., Wang H.K., Yeh C.C., Huang C.Y., Sung P.S., Wang L.C., Muo C.H., Sung F.C., Chen H.J., Li Y.C., Chang L.C., Tsai K.J.* (2014) Association between Autoimmune Rheumatic Diseases and the Risk of Dementia. BioMed Research International, 2014:861812.
Hung P.H., Huang Y.T., Hsiao C.Y., Sung P.S., Guo H.R., Tsai K.J.* (2014) Young stroke patients are at high risk for subsequent end-stage renal disease: a population-based observational study. Nephrology Dialysis Transplantation, 29(4):873-878.
Wang H.K., Tsai K.J., Huang C.Y., Wang L.C., Lu K., Chen H.J., Lin C.W., Lee Y.J., Fang P.H., Chang L.C., Li Y.C.* (2014) Newly diagnosed dementia and increased risk of hemorrhagic stroke: A nationwide population-based study. Current Alzheimer Research, 11(3):291-298.
Shih Y.H., Tsai K.J., Lee C.W., Shiesh S.C., Chen W.T., Pai M.C., Kuo Y.M.* (2014) Apolipoprotein C-III is an Amyloid-β-Binding Protein and an Early Marker for Alzheimer’s Disease. Journal of Alzheimer’s Disease, 41(3):855-865.
Tsai M.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. Journal of Pediatrics, 164(1):136-141.
Liu Y.C., Chiang P.M., Tsai K.J.* (2013) Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications. International Journal of Molecular Sciences, 14(10): 20079-20111.
Jou I.M., Lin C.F., Tsai K.J.* Wei S.J. (2013) Macrophage-mediated inflammatory disorders. Mediators of Inflammation, 2013: 316482.
Lee Y.S., Chio C.C., Chang C.P., Wang L.C., Niu K.C., and Tsai K.J.* (2013) Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke. Mediators of Inflammation, 2013:512978.
Wang I.F., Tsai K.J.* and Shen C.K.* (2013) Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: A new light for treatment of TARDBP/TDP-43 proteinopathies. Autophagy, 9(2):239-240.
Wang H.K., Lin S.H., Sung P.S., Wu M.H., Hung K.W., Wang L.C., Huang C.Y., Lu K., Chen H.J., and Tsai K.J.* (2012) Population-based study on patients with traumatic brain injury suggests increased risk of dementia. Journal of Neurology, Neurosurgery, and Psychiatry 83(11):1080-1085.
Wang L.C., Chang C.P., Chio C.C., Wu M.H., Lee Y.S., Huang C.Y., Tsai K.J.* (2012) Hypobaric hypoxia preconditioning attenuates experimental heatstroke syndromes via preinduction of heat shock protein 70. The American Journal of the Medical Sciences, 344(5):383-390.
Wang I.F., Guo B.S., Liu Y.C., Wu C.C., Yang C.H., Tsai K.J.*, Shen C.K.J.* (2012) Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proceedings of the National Academy of Science USA, 109(37):15024-15029.
Majumder P., Chen Y.T., Bose J.K., Wu C.C., Cheng W.C., Cheng S.J., Fang Y.H., Chen Y.L., Tsai K.J., Lien C.C., Shen C.K.J.* (2012) TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta Neuropathologica, 124(2):231-245.
Lin K.C., Niu K.C., Tsai K.J., Kuo J.R., Wang L.C., Chio C.C.*, and Chang C.P.* (2012) Attenuating inflammation but stimulating both angiogenesis and neurogenesis by hyperbaric oxygen in rats with traumatic brain injury. Journal of Trauma, Injury, Infection, and Critical Care, 72(3):650-659.
Wang L.C., Huang C.Y., Wang H.K., Wu M.H., and Tsai K.J.* (2012) Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. Journal of Neurotrauma, 29(7):1518-1529.
Tsai K.J., Yang C.H., Fang Y.H., Cho K.H., Chien W.L., Wang W.T., Wu T.W., Lin C.P., Fu W.M., and Shen C.K.J.* (2010) Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. Journal of Experimental Medicine, 207:1661-1673.
Tsai K.J., Yang C.H., Lee P.C., Wang W.T., Chiu M.J., and Shen C.K.J.* (2009) Asymmetric expression patterns of transthyretin transcripts in normal and a transgenic mouse model of Alzheimer’s disease. Neuroscience, 159:638-646.
Tsai K.J., Tsai Y.C. and Shen C.K.J.* (2007) G-CSF rescues the memory impairment of animal models of Alzheimer’s disease. Journal of Experimental Medicine, 204:1273-1280.
Tsai K.J., Chen S.K., Ma Y.L., Hsu W.L., and Lee E.H.Y.* (2002) Sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proceedings of the National Academy of Science USA, 99:3990-3995.
Lee E.H.Y.*, Hsieh Y.P., Yang C.L., Tsai K.J. and Liu C.H. (2000) Induction of integrin-associated protein (IAP) mRNA expression during memory consolidation in rat hippocampus. European Journal of Neuroscience, 12:1105-1112.
Lee H.M.*, Tsai K.J., Lin C.H., Huang C.L. and Tung C.S. (1998) Arecoline desensitizes carbachol-stimulated phosphatidylinositol breakdown in rat brain cortices. Journal of Neurochemistry, 70:1189-1198.

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探討以頭部外傷後之血清來調控間質幹細胞外泌體用以治療頭部外傷之療效及機制(國科會2023/08/01～ 2024/10/31)

以疾病為導向開發具基因編輯細胞治療平台－以疾病為導向開發具基因編輯細胞治療平台 (2/3) (國科會2023/05/01～ 2024/04/30)

探討自噬作用相關蛋白在阿茲海默症的致病機制與應用於奈米治療的可行性(國科會2022/08/01～ 2025/07/31)

結合創傷後電刺激及間質幹細胞注射治療腦損傷之研究(國科會2022/08/01～ 2023/10/31)

以疾病為導向開發具基因編輯細胞治療平台－以疾病為導向開發具基因編輯細胞治療平台 (1/3) (國科會2022/05/01～ 2023/04/30)

病灶旁皮質電刺激對驅動神經幹細胞修復腦傷之影響(國科會2021/08/01～ 2022/07/31)

關鍵發炎因子在額顳葉退化症影響神經新生之致病機轉探討與其相關治療策略(國科會2021/08/01～ 2022/10/31)

生醫光學影像核心平台－生醫光學影像核心平台(國科會2021/05/01～ 2022/07/31)

肥胖病患與脊椎黃韌帶肥厚之相關機轉研究-探討瘦體素與氧化壓力所扮演的角色(國科會2020/08/01～ 2021/07/31)

生醫光學影像核心平台－生醫光學影像核心平台(國科會2020/05/01～ 2021/04/30)

中大尺度意識和自主神經網路聯結度之解碼、建模和光電調節－中大尺度意識和自主神經網路聯結度之解碼、建模和光電調節(國科會2019/06/01～ 2021/06/30)

探討合併使用藥物與幹細胞治療在阿茲海默症的效用與機制之研究(國科會2017/08/01～ 2021/10/31)