| 我的研究室以診斷和治療免疫疾病為出發點,探討免疫系統執行保護人體的功能和免疫反應調控的互動機轉。從研究造成人類免疫缺損的臨床疾病出發,本研究室的研究成果已經成功釐清幾種造成本國病患免疫功能缺陷的獨特原因。以這些缺損的免疫機轉為基礎,我們成功地找出新穎的免疫調控機轉並且正積極開發免疫治療的方式。 我主要的研究興趣和一些代表性的成果如下:
1. 人類原發性免疫疾病的診斷和治療 2. 代謝免疫學在人類疾病的應用 3. 次發性免疫疾病的新穎致病原因研究 3-A. 肥胖/代謝症候群病患的免疫缺損 3-B. 「亞洲成人初發型免疫缺損」 4. 氧化還原調控免疫反應的分子機轉 5. 導向性奈米粒子用來治療免疫疾病 |
| 2024年 獲得成大醫院論文表現優異獎
2022年 專題演講(COVID19疫苗的免疫反應) 中華民國免疫學會2022年第44次會員大會暨學術研討會感謝狀 2022年 論文表現優異獎 成大醫院刊登高衝擊論文獎勵 (刊登論文影響係數7.561) 2021年 臨醫所暑期大專生培育計畫,指導醫技系學生林妙珊獲第三名 2019年 專利優化評選獲選 成功大學專利優化評選獲選專利申請補助 2016年 論文表現優異獎 成大醫院刊登高衝擊論文獎勵 (刊登論文影響係數10以上) 2016年 成功大學特聘教授 (2016-2019) 2013年 傑出研究學者獎 免疫學會 2012年 大塚醫學研究論文獎 2011年 最佳臨床研究論文獎 2007年 指導住院醫師獲小兒科醫學會論文獎 2006年 指導博士班研究論文柯林論文獎 2005年 成大醫院最佳基礎研究論文獎 免疫學會沈水德先生紀念論文獎 2004年 免疫學會劉文章教授紀念論文獎 2003年 小兒科醫學會年度論文獎 2002年小兒過敏氣喘免疫學會年度論文獎 |
| 1996.07~1997.01 美國哈佛大學Brigham and Women’s Hospital博士後研究
1997.02~迄今 國立成功大學附設醫院小兒科主治醫師 1998.08~2002.07 國立成功大學微生物及免疫學研究所助理教授、副教授、教授 2002.03~2004.07 國立成功大學附設醫院小兒過敏免疫科主任 2010.08~2023.07 總編輯/ 微免與感染雜誌雜誌 2010.08~迄今 國立成功大學臨床醫學研究所教授 2011.08~2017.07 國立成功大學臨床醫學研究所所長 2011.08~2016.07 國立成功大學醫學院附設醫院臨床醫學研究中心主任 2016.08~ 國立成功大學臨床醫學所特聘教授 2015.08~迄今 國立成功大學為生物及免疫研究所兼任教授 2017.10~迄今 財團法人國家實驗研究院國家實驗動物中心研究員 2023.08~迄今 國立成功大學醫學院附設醫院小兒免疫科主任 |
| 1. Chrong-Reen Wang, Hung-Wen Tsai, Chi-Chang Shieh (2024, Jul). Monocentric study of IL-5 monoclonal antibody induction therapy for eosinophilic granulomatosis with polyangiitis. Journal of The Formosan Medical Association. 123(7):802-810.
2. Chang-Jung Chen, Hao-Chen Wang, Ya-Chin Hou, Yi-Ying Wu, Chi-Chang Shieh, Yan-Shen Shan (2024, Jun). Blocking M2-like macrophage polarization using decoy oligodeoxynucleotide-based gene therapy prevents immune evasion for pancreatic cancer treatment. Molecular Cancer Therapeutics. DOI: 10.1158/1535-7163.MCT-23-0767. 3. Chu-Han Hsieh, Ju Lee, Hsiang-Hsuan Sung, Ya-Fang Huang, Yu-Sian Ding, Chia-Yi Li, Chia-Liang Yen, Chao-Kai Hsu, Chun-Keung Yu, Hsin-Ying Hsieh, Michael Warren Hughes, Peng-Chieh Chen, Chi-Chang Shieh (2023, Dec). Novel SLC5A6 Mutations Lead to B Lymphocyte Maturation 1 Defects with Metabolic Abnormality Rescuable by Biotin Replenishment. Clinical Immunology. DOI: 10.1016/j.clim.2023.109855. nstc 109-2314-B-006-049. 本人為通訊作者. 4. Po-Sung Chen, Ju Lee, Hui-Ping Pan, Yuh-Jyh Lin, Yung-Chieh Lin, Yu-Shan Chang, Yen-Ju Chen, Chia-Liang Yen, Ching-Wei Lin, Chih-An Chen, Chi-Chang Shieh (2023, Aug). Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening. Journal of Microbiology, Immunology and Infection, 56(4):871-874. 本人為通訊作者. 5. Ching-Fen Shen, Yi-Chen Fu, Tzong-Shiann Ho, Po-Lin Chen, Nan-Yao Lee, Bo-Yang Tsai, Pei-Jane Tsai, Wen-Chien Ko, Ching-Chuan Liu, Chao-Min Cheng, Chi-Chang Shieh (2023, Jun). Pre-existing humoral immunity and CD4+ T cell response correlate with cross-reactivity against SARS-CoV-2 Omicron subvariants after heterologous prime-boost vaccination. Clinical Immunology, https://doi.org/10.1016/j.clim.2023.109342. nstc 111-2628-E-007-005-MY2. 本人為通訊作者. 6. Chin-Wei Kuo, Po-Lan Su, Tang-Hsiu Huang, Chien-Chung Lin, Chian-Wei Chen, Jeng-Shiuan Tsai, Xin-Min Liao, Tzu-Yi Chan & Chi-Chang Shieh (2023, May). Cigarette smoke increases susceptibility of alveolar macrophages to SARS-CoV-2 infection through inducing reactive oxygen species-upregulated angiotensin-converting enzyme 2 expression. Scientific Reports, https://doi.org/ 10.1038/s41598-023-34785-6. 本人為通訊作者. 7. Ho-Ching Chen, Hsin-Yu Hou, Junne-Ming Sung, Chi-Chang Shieh (2023, Mar). Deletion of NADPH oxidase 2 attenuates cisplatin-induced acute kidney injury through reducing ROS-induced proximal tubular cell injury and inflammation. Frontiers in Medicine, DOI 10.3389/fmed.2023.1097671. 本人為通訊作者. 8. Chun-Hsin Wu, Chih-An Chen, Sheng-Hsiang Lin, Chia-Tse Weng, Pao-Lin Kuo, Chi-Chang Shieh (2022, Sep). Increased risk of early-onset childhood systemic lupus erythematosus for children born to affected parents: A nationwide child-parent cohort study. Frontiers in Immunology, DOI: 10.3389/fimmu.2022.966809. 本人為通訊作者. 9. Ching-Fen Shen, Chia-Liang Yen, Yi-Chen Fu, Chao-Min Cheng, Tzu-Chi Shen, Pei-De Chang, Kuang-Hsiung Cheng, Ching-Chuan Liu, Yu-Tzu Chang, Po-Lin Chen, Wen-Chien Ko, Chi-Chang Shieh (2022, Jan). Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination. Frontiers in Immunology, doi.org/10.3389/fimmu.2022.807454. MOST 110-2923-B-006-001-MY4. 本人為通訊作者. 10. Yi-Chu Liao, Szu-Yu Wu, Ya-Fang Huang, Pei-Chi Lo, Tzu-Yi Chan, Chih-An Chen, Chun-Hsin Wu, Che-Chia Hsu, Chia-Liang Yen, Peng-Chieh Chen, ChiChang Shieh (2021, Sep). NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities. Frontiers in Immunology, https://doi.org/10.3389/fimmu.2021.743030. MOST 109-2314-B-006-049. 本人為通訊作者. 11. Chun-Chieh Lai, Sung-Huei Tseng, Sheng-Min Hsu, Yin-Ting Huang, ChiChang Shieh (2021, Aug). Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultravioletv Light–Induced Pterygium. Investigative Ophthalmology & Visual Science, 62(10):6. doi: 10.1167/iovs.62.10.6. 本人為通訊作者. 12. Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, JingWun Chen, Shih-Heng Chen, Jau-Shyong Hong, and Shyi-Jou Chen (2021, Apr). Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology, doi: 10.3389/fimmu.2021.638381. eCollection 2021. 13. Sheng-Min Hsu, Chang-Hao Yang, Hsien-Yang Tsai, Chia-Jhen Lin, Yi-Hsuan Fang, Chi-Chang Shieh, Shun-Hua Chen (2020, Nov). Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice. International Journal of Molecular Science, 2020 Nov 6;21(21):8326. doi: 10.3390/ijms21218326. 14. Li-Hui Wang, Wei-Ming Wang, Chun-Yu Lin, Sheng-Hsiang Lin, Chi-Chang Shieh (2020, Sep). Bidirectional Relationship Between Primary Sjögren’s Syndrome and Non- Hodgkin’s Lymphoma: A Nationwide Taiwanese Population-based Study. The Journal of Rheumatology, 47 (9) 1374-1378. 本人 為通訊作者. 15. Yung-Chieh Lin, Yen-Ju Chen, Chao-Ching Huang, Chi-Chang Shieh (2020, Aug). Concentrated Preterm Formula as a Liquid Human Milk Fortifier at Initiation Stage in Extremely Low Birth Weight Preterm Infants: Short Term and 2-year Follow-up Outcomes. Nutrients, Nutrients 2020, 12(8), 2229. 本人為通訊作者. 16. Sheng-Min Hsu, Chang-Hao Yang, Yu-Ti Teng, Hsien-Yang Tsai, Chieh-Yu Lin, Chia-Jhen Lin, Chi-Chang Shieh, Shun-Hua Chen (2020, May). Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice. International Journal of Molecular Sciences, 2020 May 5;21(9):3261. 17. Wen-Cheng Chao, Chia-Liang Yen, Chun-Hsin Wu, Chi-Chang Shieh (2020, Apr). How mycobacteria take advantage of the weakness in human immune system in the modern world. Journal of Microbiology, Immunology and Infection, 53(2), 209-215. 18. Cheng-Yu Liao, Hui-Wen Yu, Chao-Neng Cheng, Jiann-Shiuh Chen, Ching-Wei Lin, Peng-Chieh Chen, Chi-Chang Shieh (2020, Feb). A novel pathogenic mutation on Interleukin-7 receptor leading to severe combined immunodeficiency identified with newborn screening and whole exome sequencing. Journal of Microbiology, Immunology and Infection, 53, 99-105. 本人為通訊作者. 19. Tzu-Yi Chan, Chia-Liang Yen, Ya-Fang Huang, Pei-Chi Lo, Peter A Nigrovic, Chia-Ying Cheng, Wei-Zhi Wang, Szu-Yu Wu, Chi-Chang Shieh (2019, Nov). Increased ILC3s associated with higher levels of IL-1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase. European Journal of Immunology, 49 (11): 2063-2073. MOST 106-2314-B-006-057-MY3. 本人為通 訊作者. 20. Chin-Wei Kuo, Xin-Min Liao, Yi-Ching Huang, Han-Yu Chang & Chi-Chang Shieh (2019, Oct). Bronchoscopy-guided bronchial epithelium sampling as a tool for selecting the optimal biologic treatment in a patient with severe asthma: a case report. Allergy, Asthma & Clinical Immuology, DOI: 10.1186/s13223-019- 0378-6. 本人為通訊作者 21. Li-Hui Wang, Wei-Ming Wang, Sheng-Hsiang Lin, Chi-Chang Shieh (2019, Jul). Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study. RHEUMATOLOGY, 1;58(7):1245-1249. 本人為通訊作者. 22. Chia-Liang Yen, Yi-Chu Liao, Ru-Fen Chen, Ya-Fang Huang, Wan-Chen Chung, Pei-Chi Lo, Chuan-Fa Chang, Ping-Ching Wu, Dar-Bin Shieh, Si-Tse Jiang, Chi-Chang Shieh (2019, Jun). Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis. The Journal of Immunology, 2019 Jun 15;202(12):3394-3403. MOST 105-2325- B-006-008. 本人為通訊作者. 23. Ho-Ching Chen, Chi-Chang Shieh, Junne-Ming Sung (2018, Jun). Increasing Staphylococcus Species Resistance in Peritoneal Dialysis-Related Peritonitis over a 10-Year Period in a Single Taiwanese Center. Peritoneal Dialysis International, 2018 Jul-Aug;38(4):266-270 |
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